1-(3-((4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)phenyl)-1-oxo-5,8,11-trioxa-2-azatetradecan-14-oic acid

Base Information

Chemical Name:1-(3-((4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)phenyl)-1-oxo-5,8,11-trioxa-2-azatetradecan-14-oic acid
CAS No.:1354721-85-9
Molecular Formula:C₃₄H₃₃ClF₃N₅O₈
Molecular Weight:732.113
Hs Code.:

Synonyms:1-(3-((4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)phenyl)-1-oxo-5,8,11-trioxa-2-azatetradecan-14-oic acid

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Chemical Property of 1-(3-((4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)phenyl)-1-oxo-5,8,11-trioxa-2-azatetradecan-14-oic acid

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Technology Process of 1-(3-((4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)phenyl)-1-oxo-5,8,11-trioxa-2-azatetradecan-14-oic acid

There total 10 articles about 1-(3-((4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)phenyl)-1-oxo-5,8,11-trioxa-2-azatetradecan-14-oic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354722-37-4
tert-butyl1-(3-((4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)phenyl)-1-oxo-5,8,11-trioxa-2-azatetradecan-14-oate

: 1354721-85-9
1-(3-((4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)phenyl)-1-oxo-5,8,11-trioxa-2-azatetradecan-14-oic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 0.5h;

Reference yield:

: 401-81-0
m-trifluoromethylphenyl iodide

: 1354721-85-9
1-(3-((4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)phenyl)-1-oxo-5,8,11-trioxa-2-azatetradecan-14-oic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate; L-proline; copper(l) iodide / dimethyl sulfoxide / 85 °C

2.1: hydrogen / palladium on activated charcoal / methanol / 20 °C

3.1: pyridine / 1 h / 20 °C

4.1: zinc; acetic acid / 1 h / 70 °C

4.2: pH 8

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane; tetrahydrofuran / 1 h

6.1: trifluoroacetic acid / dichloromethane / 0.5 h

With pyridine; copper(l) iodide; hydrogen; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; L-proline; zinc; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1354722-12-5
3-nitro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazole

: 1354721-85-9
1-(3-((4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)phenyl)-1-oxo-5,8,11-trioxa-2-azatetradecan-14-oic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium on activated charcoal / methanol / 20 °C

2.1: pyridine / 1 h / 20 °C

3.1: zinc; acetic acid / 1 h / 70 °C

3.2: pH 8

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane; tetrahydrofuran / 1 h

5.1: trifluoroacetic acid / dichloromethane / 0.5 h

With pyridine; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; zinc; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;