(-)-Menthyl hydroxyacetate

Base Information

• Chemical Name: (-)-Menthyl hydroxyacetate
• CAS No.: 64850-52-8
• Molecular Formula: C₁₂H₂₂O₃
• Molecular Weight: 214.305
• Mol file: 64850-52-8.mol

Synonyms:(-)-Menthyl hydroxyacetate

Chemical Property of (-)-Menthyl hydroxyacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (-)-Menthyl hydroxyacetate

There total 1 articles about (-)-Menthyl hydroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

glycolic Acid (79-14-1) + (-)-menthol (2216-51-5) → (-)-Menthyl hydroxyacetate (64850-52-8)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; Heating;

DOI:10.1002/prac.19943360317

Reference yield: 95.0%

(-)-Menthyl hydroxyacetate (64850-52-8) + tert-butyldimethylsilyl chloride (18162-48-6) → (-)-Menthyl t-butyldimethylsilyloxyacetate (132155-24-9)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; for 20h; Ambient temperature;

DOI:10.1016/S0040-4020(01)91210-4

Reference yield:

(-)-Menthyl hydroxyacetate (64850-52-8) → Acetylamino-hydroxy-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / P₂O₅, DMSO / CH₂Cl₂ / Ambient temperature

2: ethyl acetate / 1.5 h / Heating

With phosphorus pentoxide; dimethyl sulfoxide; In dichloromethane; ethyl acetate;

DOI:10.1002/prac.19943360317

upstream raw materials:

glycolic Acid

(-)-menthol

Downstream raw materials:

(-)-Menthyl t-butyldimethylsilyloxyacetate