N-(3-chloro-4-((3-fluorobenzyl)oxyphenyl)-6-(5-((4-hydroxybutyl)amino)formyl)-2-furyl)-4-quinazolinamine

Base Information

Chemical Name:N-(3-chloro-4-((3-fluorobenzyl)oxyphenyl)-6-(5-((4-hydroxybutyl)amino)formyl)-2-furyl)-4-quinazolinamine
CAS No.:1421356-85-5
Molecular Formula:C₃₀H₂₆ClFN₄O₄
Molecular Weight:561.012
Hs Code.:

Synonyms:N-(3-chloro-4-((3-fluorobenzyl)oxyphenyl)-6-(5-((4-hydroxybutyl)amino)formyl)-2-furyl)-4-quinazolinamine

Suppliers and Price of N-(3-chloro-4-((3-fluorobenzyl)oxyphenyl)-6-(5-((4-hydroxybutyl)amino)formyl)-2-furyl)-4-quinazolinamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(3-chloro-4-((3-fluorobenzyl)oxyphenyl)-6-(5-((4-hydroxybutyl)amino)formyl)-2-furyl)-4-quinazolinamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(3-chloro-4-((3-fluorobenzyl)oxyphenyl)-6-(5-((4-hydroxybutyl)amino)formyl)-2-furyl)-4-quinazolinamine

There total 4 articles about N-(3-chloro-4-((3-fluorobenzyl)oxyphenyl)-6-(5-((4-hydroxybutyl)amino)formyl)-2-furyl)-4-quinazolinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13325-10-5
4-Aminobutanol

: 1152131-73-1
5-{4-[3-chloro-4-(3-fluorobenzyloxy)phenylamino]quinazolin-6-yl}furan-2-carboxylic acid

: 1421356-85-5
N-(3-chloro-4-((3-fluorobenzyl)oxyphenyl)-6-(5-((4-hydroxybutyl)amino)formyl)-2-furyl)-4-quinazolinamine

Guidance literature:: 5-{4-[3-chloro-4-(3-fluorobenzyloxy)phenylamino]quinazolin-6-yl}furan-2-carboxylic acid; With thionyl chloride; In chloroform; N,N-dimethyl-formamide; at 20 ℃; for 6h;

4-Aminobutanol; In chloroform; N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 231278-20-9
N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-amine

: 1421356-85-5
N-(3-chloro-4-((3-fluorobenzyl)oxyphenyl)-6-(5-((4-hydroxybutyl)amino)formyl)-2-furyl)-4-quinazolinamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; palladium 10% on activated carbon / water; methanol; 1,2-dimethoxyethane / 24 h / 50 °C

2.1: tetrabutylammomium bromide; potassium permanganate / water; tetrahydrofuran / 24 h / 20 °C / Cooling with ice

3.1: thionyl chloride / N,N-dimethyl-formamide; chloroform / 6 h / 20 °C

3.2: 24 h / 20 °C

With potassium permanganate; thionyl chloride; palladium 10% on activated carbon; tetrabutylammomium bromide; triethylamine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; chloroform; water; N,N-dimethyl-formamide;

Reference yield:

: 231278-84-5
5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde

: 1421356-85-5
N-(3-chloro-4-((3-fluorobenzyl)oxyphenyl)-6-(5-((4-hydroxybutyl)amino)formyl)-2-furyl)-4-quinazolinamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutylammomium bromide; potassium permanganate / water; tetrahydrofuran / 24 h / 20 °C / Cooling with ice

2.1: thionyl chloride / N,N-dimethyl-formamide; chloroform / 6 h / 20 °C

2.2: 24 h / 20 °C

With potassium permanganate; thionyl chloride; tetrabutylammomium bromide; In tetrahydrofuran; chloroform; water; N,N-dimethyl-formamide;