(1r,4r)-4-(1-(5-(trifluoromethyl)-1 ,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexyl 2,2,2-trifluoroacetate

Base Information

Chemical Name:(1r,4r)-4-(1-(5-(trifluoromethyl)-1 ,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexyl 2,2,2-trifluoroacetate
CAS No.:1415818-29-9
Molecular Formula:C₁₆H₁₉F₆N₃O₄
Molecular Weight:431.335
Hs Code.:

Synonyms:(1r,4r)-4-(1-(5-(trifluoromethyl)-1 ,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexyl 2,2,2-trifluoroacetate

Suppliers and Price of (1r,4r)-4-(1-(5-(trifluoromethyl)-1 ,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexyl 2,2,2-trifluoroacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (1r,4r)-4-(1-(5-(trifluoromethyl)-1 ,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexyl 2,2,2-trifluoroacetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1r,4r)-4-(1-(5-(trifluoromethyl)-1 ,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexyl 2,2,2-trifluoroacetate

There total 10 articles about (1r,4r)-4-(1-(5-(trifluoromethyl)-1 ,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexyl 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415818-27-7
C₁₂H₂₃N₃O₃

: 407-25-0
trifluoroacetic anhydride

: 1415818-28-8
(1r,4r)-4-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexanol

: 1415818-29-9
(1r,4r)-4-(1-(5-(trifluoromethyl)-1 ,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexyl 2,2,2-trifluoroacetate

Guidance literature:: With triethylamine; In dichloromethane; at 35 ℃; for 3h;

Reference yield:

: 1338556-37-8
(1r,4r)-4-(pyridin-4-yloxy)cyclohexanol

: 1415818-28-8
(1r,4r)-4-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexanol

: 1415818-29-9
(1r,4r)-4-(1-(5-(trifluoromethyl)-1 ,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexyl 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1: ISOPROPYLAMIDE; tetrahydrofuran

2: sodium tetrahydroborate; methanol / 20 °C / Cooling with ice

3: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 2585.81 Torr

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

5: hydroxylamine / ethanol / 4 h / 75 °C

6: triethylamine / dichloromethane / 3 h / 35 °C

With methanol; sodium tetrahydroborate; hydrogen; hydroxylamine; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; ISOPROPYLAMIDE;

Reference yield:

: 22428-87-1
4,4-ethylenedioxycyclohexan-1-ol

: 1415818-28-8
(1r,4r)-4-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexanol

: 1415818-29-9
(1r,4r)-4-(1-(5-(trifluoromethyl)-1 ,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexyl 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium t-butanolate / dimethyl sulfoxide / 4 h / 40 - 80 °C

2.1: hydrogenchloride; water / 50 °C

2.2: 0.17 h / 20 °C / pH 6

2.3: 0.17 h / pH 7 - 8

3.1: sodium tetrahydroborate; methanol / 11 - 36 °C

3.2: 0.5 h

3.3: pH 8

4.1: ISOPROPYLAMIDE; tetrahydrofuran

5.1: sodium tetrahydroborate; methanol / 20 °C / Cooling with ice

6.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 2585.81 Torr

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

8.1: hydroxylamine / ethanol / 4 h / 75 °C

9.1: triethylamine / dichloromethane / 3 h / 35 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; water; hydrogen; hydroxylamine; triethylamine; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; dimethyl sulfoxide;