(1r,4r)-4-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexanol

Base Information

Chemical Name:(1r,4r)-4-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexanol
CAS No.:1415818-28-8
Molecular Formula:C₁₄H₂₀F₃N₃O₃
Molecular Weight:335.326
Hs Code.:

Synonyms:(1r,4r)-4-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexanol

Suppliers and Price of (1r,4r)-4-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1r,4r)-4-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1r,4r)-4-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexanol

There total 20 articles about (1r,4r)-4-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415818-27-7
C₁₂H₂₃N₃O₃

: 407-25-0
trifluoroacetic anhydride

: 1415818-28-8
(1r,4r)-4-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexanol

Guidance literature:: C₁₂H₂₃N₃O₃; trifluoroacetic anhydride; With triethylamine; In dichloromethane; at 35 ℃; for 1h;

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 1415818-27-7
C₁₂H₂₃N₃O₃

: 407-25-0
trifluoroacetic anhydride

: 1415818-28-8
(1r,4r)-4-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexanol

: 1415818-29-9
(1r,4r)-4-(1-(5-(trifluoromethyl)-1 ,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexyl 2,2,2-trifluoroacetate

Guidance literature:: With triethylamine; In dichloromethane; at 35 ℃; for 3h;

Reference yield:

: 22428-87-1
4,4-ethylenedioxycyclohexan-1-ol

: 1415818-28-8
(1r,4r)-4-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexanol

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium t-butanolate / dimethyl sulfoxide / 4 h / 40 - 80 °C

2.1: hydrogenchloride; water / 50 °C

2.2: 0.17 h / 20 °C / pH 6

2.3: 0.17 h / pH 7 - 8

3.1: sodium tetrahydroborate; methanol / 11 - 36 °C

3.2: 0.5 h

3.3: pH 8

4.1: ISOPROPYLAMIDE; tetrahydrofuran

5.1: sodium tetrahydroborate; methanol / 20 °C / Cooling with ice

6.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 2585.81 Torr

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

8.1: hydroxylamine / ethanol / 4 h / 75 °C

9.1: triethylamine / dichloromethane / 1 h / 35 °C

9.2: 1 h / 20 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; water; hydrogen; hydroxylamine; triethylamine; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; dimethyl sulfoxide;