N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,4-dimethyl-2-methylenepentanamide

Base Information

Chemical Name:N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,4-dimethyl-2-methylenepentanamide
CAS No.:1068601-75-1
Molecular Formula:C₁₇H₂₅NO₂
Molecular Weight:275.391
Hs Code.:

Synonyms:N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,4-dimethyl-2-methylenepentanamide

Suppliers and Price of N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,4-dimethyl-2-methylenepentanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,4-dimethyl-2-methylenepentanamide

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Technology Process of N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,4-dimethyl-2-methylenepentanamide

There total 1 articles about N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,4-dimethyl-2-methylenepentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 25044-10-4
2-methylene-4-methyl-pentanoic acid

: 90-82-4,7009-81-6,90-83-5,6912-63-6
pseudoephedrine

: 1068601-75-1
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,4-dimethyl-2-methylenepentanamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In water; N,N-dimethyl-formamide; at 0 - 23 ℃; Inert atmosphere;
DOI:10.1021/ja806021y

Reference yield: 91.0%

: 1068601-75-1
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,4-dimethyl-2-methylenepentanamide

: 591-51-5
phenyllithium

: 74-88-4
methyl iodide

: 1068602-38-9
(R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2,4-trimethylpentanamide

Guidance literature:: N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,4-dimethyl-2-methylenepentanamide; With methyllithium; lithium chloride; In tetrahydrofuran; formaldehyde diethyl acetal; at -78 ℃; Inert atmosphere;

phenyllithium; In tetrahydrofuran; formaldehyde diethyl acetal; dibutyl ether; at -78 - 0 ℃; Inert atmosphere;

methyl iodide; In tetrahydrofuran; formaldehyde diethyl acetal; dibutyl ether; at 0 ℃; for 2.5h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ja806021y