(R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2,4-trimethylpentanamide

Base Information

Chemical Name:(R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2,4-trimethylpentanamide
CAS No.:1068602-38-9
Molecular Formula:C₂₄H₃₃NO₂
Molecular Weight:367.532
Hs Code.:

Synonyms:(R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2,4-trimethylpentanamide

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Chemical Property of (R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2,4-trimethylpentanamide

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Technology Process of (R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2,4-trimethylpentanamide

There total 2 articles about (R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2,4-trimethylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1068601-75-1
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,4-dimethyl-2-methylenepentanamide

: 591-51-5
phenyllithium

: 74-88-4
methyl iodide

: 1068602-38-9
(R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2,4-trimethylpentanamide

Guidance literature:: N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,4-dimethyl-2-methylenepentanamide; With methyllithium; lithium chloride; In tetrahydrofuran; formaldehyde diethyl acetal; at -78 ℃; Inert atmosphere;

phenyllithium; In tetrahydrofuran; formaldehyde diethyl acetal; dibutyl ether; at -78 - 0 ℃; Inert atmosphere;

methyl iodide; In tetrahydrofuran; formaldehyde diethyl acetal; dibutyl ether; at 0 ℃; for 2.5h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ja806021y

Reference yield:

: 513-38-2
Isobutyl iodide

: 159345-06-9,352530-53-1
(2R)-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethyl-3-phenylpropionamide

: 1068602-38-9
(R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2,4-trimethylpentanamide

: 1068601-43-3
(2S)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2,4-trimethylpentanamide

Guidance literature:: (2R)-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethyl-3-phenylpropionamide; With n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; hexane; at -78 - 0 ℃; Inert atmosphere;

Isobutyl iodide; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In tetrahydrofuran; hexane; at -40 ℃; for 24.25h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ja806021y

Reference yield: 82.0%

: 1068602-38-9
(R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2,4-trimethylpentanamide

: 1068602-62-9
(2R)-2-benzyl-2,4-dimethylpentanoic acid

Guidance literature:: With tetra(n-butyl)ammonium hydroxide; water; In 1,4-dioxane; at 115 ℃; for 15h; Inert atmosphere;
DOI:10.1021/ja806021y