C₁₂H₁₃IO₄

Base Information

• Chemical Name: C₁₂H₁₃IO₄
• CAS No.: 124604-05-3
• Molecular Formula: C₁₂H₁₃IO₄
• Molecular Weight: 348.137
• Mol file: 124604-05-3.mol

Synonyms:C₁₂H₁₃IO₄

Chemical Property of C₁₂H₁₃IO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₁₃IO₄

There total 3 articles about C₁₂H₁₃IO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-benzyl-malonic acid dimethyl ester (49769-78-0) → C12H13IO4 (124604-05-3)

Guidance literature:

With potassium 1-hydroxy-1,3-dioxo-1,3-dihydro-1λ(5)-benziodoxol-5-sulfonate; sodium iodide; In water; dimethyl sulfoxide; at 50 ℃; for 2h;

DOI:10.1002/anie.201402433

Reference yield:

malonic acid dimethyl ester (108-59-8) → C12H13IO4 (124604-05-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 23 °C / Inert atmosphere

1.2: 2 h / 23 °C

2.1: sodium iodide; potassium 1-hydroxy-1,3-dioxo-1,3-dihydro-1λ(5)-benziodoxol-5-sulfonate / dimethyl sulfoxide; water / 2 h / 50 °C

With potassium 1-hydroxy-1,3-dioxo-1,3-dihydro-1λ(5)-benziodoxol-5-sulfonate; sodium hydride; sodium iodide; In tetrahydrofuran; water; dimethyl sulfoxide;

DOI:10.1002/anie.201402433

Reference yield:

benzyl bromide (100-39-0) → C12H13IO4 (124604-05-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 23 °C / Inert atmosphere

1.2: 2 h / 23 °C

2.1: sodium iodide; potassium 1-hydroxy-1,3-dioxo-1,3-dihydro-1λ(5)-benziodoxol-5-sulfonate / dimethyl sulfoxide; water / 2 h / 50 °C

With potassium 1-hydroxy-1,3-dioxo-1,3-dihydro-1λ(5)-benziodoxol-5-sulfonate; sodium hydride; sodium iodide; In tetrahydrofuran; water; dimethyl sulfoxide;

DOI:10.1002/anie.201402433

upstream raw materials:

2-benzyl-malonic acid dimethyl ester

malonic acid dimethyl ester

benzyl bromide

Downstream raw materials:

2-Azido-3-phenylpropionsaeure-methylester

methyl 3-phenyl-2-(4-phenyl-1H-1,2,3-triazol-1-yl)propanoate

1-Iodo-1-methoxycarbonyl-2-phenylethane

C₁₁H₁₁IO₄