methyl 3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoate

Base Information

Chemical Name:methyl 3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoate
CAS No.:1007099-05-9
Molecular Formula:C₁₉H₁₄F₂N₂O₃
Molecular Weight:356.329
Hs Code.:

Synonyms:methyl 3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoate

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Chemical Property of methyl 3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoate

Chemical Property:

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Technology Process of methyl 3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoate

There total 4 articles about methyl 3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1007098-93-2
6-(3,5-difluorophenyl)pyridazine-3(2H)-one

: 1129-28-8
3-methoxycarbonylbenzyl bromide

: 1007099-05-9
methyl 3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide;

Reference yield:

: 156545-07-2
3,5-difluorophenylboronic acid

: 1007099-05-9
methyl 3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water / 5 h / 100 °C

2: water; formic acid / 18 h / Heating

3: caesium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C

With formic acid; water; sodium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 123577-99-1
3′,5′-difluoroacetophenone

: 1007099-05-9
methyl 3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / 18 h / 95 °C

1.2: 4 h / 30 - 95 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C

With caesium carbonate; acetic acid; In N,N-dimethyl-formamide;