4-(6-phenyl-1,4-dioxaspiro[4.5]decan-6-yl)butanoic acid

Base Information

Chemical Name:4-(6-phenyl-1,4-dioxaspiro[4.5]decan-6-yl)butanoic acid
CAS No.:1356465-27-4
Molecular Formula:C₁₈H₂₄O₄
Molecular Weight:304.386
Hs Code.:

Synonyms:4-(6-phenyl-1,4-dioxaspiro[4.5]decan-6-yl)butanoic acid

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Chemical Property of 4-(6-phenyl-1,4-dioxaspiro[4.5]decan-6-yl)butanoic acid

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Technology Process of 4-(6-phenyl-1,4-dioxaspiro[4.5]decan-6-yl)butanoic acid

There total 6 articles about 4-(6-phenyl-1,4-dioxaspiro[4.5]decan-6-yl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356465-25-2
methyl 4-(6-phenyl-1,4-dioxaspiro[4.5]decan-6-yl)butanoate

: 1356465-27-4
4-(6-phenyl-1,4-dioxaspiro[4.5]decan-6-yl)butanoic acid

Guidance literature:: methyl 4-(6-phenyl-1,4-dioxaspiro[4.5]decan-6-yl)butanoate; With methanol; sodium hydroxide; at 20 ℃; for 4h;

With hydrogenchloride; In water;

Reference yield:

: 1444-65-1
(RS)-2-phenylcyclohexanone

: 1356465-27-4
4-(6-phenyl-1,4-dioxaspiro[4.5]decan-6-yl)butanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hexamethyldisilazane / 1,2-dimethoxyethane / 0.33 h / Cooling with ice

1.2: 0.33 h / 20 °C

1.3: 2 h / 20 °C

2.1: toluene-4-sulfonic acid / benzene / 16.5 h / Reflux

3.1: sodium periodate / osmium(VIII) oxide / water; tert-butyl alcohol / 3 h

4.1: tetrahydrofuran / 18 h / Reflux

5.1: hydrogen / palladium 10% on activated carbon / methanol / 3.5 h / 1292.9 Torr

6.1: sodium hydroxide; methanol / 4 h / 20 °C

With methanol; sodium periodate; hydrogen; sodium hexamethyldisilazane; toluene-4-sulfonic acid; sodium hydroxide; osmium(VIII) oxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; tert-butyl alcohol; benzene;

Reference yield:

: 7079-07-4
2-allyl-2-phenylcyclohexan-1-one

: 1356465-27-4
4-(6-phenyl-1,4-dioxaspiro[4.5]decan-6-yl)butanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / benzene / 16.5 h / Reflux

2: sodium periodate / osmium(VIII) oxide / water; tert-butyl alcohol / 3 h

3: tetrahydrofuran / 18 h / Reflux

4: hydrogen / palladium 10% on activated carbon / methanol / 3.5 h / 1292.9 Torr

5: sodium hydroxide; methanol / 4 h / 20 °C

With methanol; sodium periodate; hydrogen; toluene-4-sulfonic acid; sodium hydroxide; osmium(VIII) oxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; tert-butyl alcohol; benzene;