β-(3,5-Dimethylphenyl)ethanesulfonamide

Base Information

• Chemical Name: β-(3,5-Dimethylphenyl)ethanesulfonamide
• CAS No.: 93427-12-4
• Molecular Formula: C₁₀H₁₅NO₂S
• Molecular Weight: 213.301
• Mol file: 93427-12-4.mol

Synonyms:β-(3,5-Dimethylphenyl)ethanesulfonamide

Chemical Property of β-(3,5-Dimethylphenyl)ethanesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of β-(3,5-Dimethylphenyl)ethanesulfonamide

There total 4 articles about β-(3,5-Dimethylphenyl)ethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

β-(3,5-Dimethylphenyl)ethanesulfonyl chloride (88106-98-3) → β-(3,5-Dimethylphenyl)ethanesulfonamide (93427-12-4)

Guidance literature:

With ammonia; In diethyl ether; for 2h;

DOI:10.1021/jo00200a022

Reference yield: 7.2%

β-(3,5-Dimethylphenyl)ethanesulfonyl azide (70555-51-0) → 6,8-Dimethyl-3,4-dihydro-2,1-benzothiazine 2,2-dioxide (70555-52-1) + β-(3,5-Dimethylphenyl)ethanesulfonamide (93427-12-4)

Guidance literature:

In 1,1,2-Trichloro-1,2,2-trifluoroethane; at 135 ℃; for 36h; Product distribution; Mechanism;

DOI:10.1021/jo00200a022

Reference yield:

β-(3,5-Dimethylphenyl)ethyl bromide (93427-11-3) → β-(3,5-Dimethylphenyl)ethanesulfonamide (93427-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) anhydrous sodium sulfite 2) dimethylformamide, thionyl chloride / 1) water, reflux, 24 h 2) benzene, reflux, 4h

2: 85 percent / ammonia gas / diethyl ether / 2 h

With thionyl chloride; ammonia; N,N-dimethyl-formamide; sodium sulfite; In diethyl ether;

DOI:10.1021/jo00200a022

upstream raw materials:

β-(3,5-Dimethylphenyl)ethanesulfonyl azide

β-(3,5-Dimethylphenyl)ethanesulfonyl chloride

β-(3,5-Dimethylphenyl)ethyl bromide

β-(3,5-Dimethylphenyl)ethyl alcohol

Refernces