(S)-3-(4-chlorophenyl)-3-(1H-indol-3-yl)-1-phenylpropan-1-one

Base Information

• Chemical Name: (S)-3-(4-chlorophenyl)-3-(1H-indol-3-yl)-1-phenylpropan-1-one
• CAS No.: 1007562-87-9
• Molecular Formula: C₂₃H₁₈ClNO
• Molecular Weight: 359.855
• Mol file: 1007562-87-9.mol

Synonyms:(S)-3-(4-chlorophenyl)-3-(1H-indol-3-yl)-1-phenylpropan-1-one

Chemical Property of (S)-3-(4-chlorophenyl)-3-(1H-indol-3-yl)-1-phenylpropan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-(4-chlorophenyl)-3-(1H-indol-3-yl)-1-phenylpropan-1-one

There total 3 articles about (S)-3-(4-chlorophenyl)-3-(1H-indol-3-yl)-1-phenylpropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

indole (120-72-9) + 3-(4-chlorophenyl)-1-phenylprop-2-en-1-one (956-04-7) → (S)-3-(4-chlorophenyl)-3-(1H-indol-3-yl)-1-phenylpropan-1-one (1007562-87-9)

Guidance literature:

With (S)-4-isopropyl-2-(3-((S)-4-isopropyl-1-(4-methoxyphenyl)-4,5-dihydro-1H-imidazol-2-yl)pentan-3-yl)-4,5-dihydrooxazole; copper(II) bis(trifluoromethanesulfonate); In acetonitrile; at 20 ℃; for 24h; enantioselective reaction; Inert atmosphere; Glovebox; Schlenk technique;

DOI:10.1016/j.tet.2013.04.063

Reference yield: 84.0%

indole (120-72-9) + (2Z)-3-(4-chlorophenyl)-1-phenylprop-2-en-1-one (24721-26-4) → (S)-3-(4-chlorophenyl)-3-(1H-indol-3-yl)-1-phenylpropan-1-one (1007562-87-9)

Guidance literature:

With C₂₆H₃₇CuF₆N₃O₈S₂; In acetonitrile; at 20 ℃; enantioselective reaction; Inert atmosphere;

DOI:10.1016/j.bioorg.2018.05.004

Reference yield: 84.0%

→ (S)-3-(4-chlorophenyl)-3-(1H-indol-3-yl)-1-phenylpropan-1-one (1007562-87-9)

Guidance literature:

With (S)-4-isopropyl-2-(3-((S)-4-isopropyl-1-(4-methoxyphenyl)-4,5-dihydro-1H-imidazol-2-yl)pentan-3-yl)-4,5-dihydrooxazole; copper(II) bis(trifluoromethanesulfonate); In acetonitrile; at 20 ℃; enantioselective reaction; Inert atmosphere;

upstream raw materials:

indole

3-(4-chlorophenyl)-1-phenylprop-2-en-1-one

(2Z)-3-(4-chlorophenyl)-1-phenylprop-2-en-1-one