5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-chloroaniline

Base Information

• Chemical Name: 5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-chloroaniline
• CAS No.: 1071927-85-9
• Molecular Formula: C₁₆H₁₀Cl₃F₃N₂O
• Molecular Weight: 409.622
• Mol file: 1071927-85-9.mol

Synonyms:5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-chloroaniline

Chemical Property of 5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-chloroaniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-chloroaniline

There total 6 articles about 5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-chloroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-chloronitrobenzene (1071928-04-5) → 5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-chloroaniline (1071927-85-9)

Guidance literature:

With iron; acetic acid; In ethanol; water; at 20 - 75 ℃;

Reference yield:

2-chloro-5-hydroxyiminomethylnitrobenzene (66399-01-7) → 5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-chloroaniline (1071927-85-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 60 °C

1.2: 6 h / 20 °C

2.1: water; acetic acid; iron / ethanol / 0.83 h / 75 °C

With N-chloro-succinimide; water; iron; acetic acid; In ethanol; N,N-dimethyl-formamide;

Reference yield:

1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene (864725-22-4) → 5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-chloroaniline (1071927-85-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 60 °C

1.2: 6 h / 20 °C

2.1: water; acetic acid; iron / ethanol / 0.83 h / 75 °C

With N-chloro-succinimide; water; iron; acetic acid; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-chloronitrobenzene

bis(trichloromethyl) carbonate

1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

2-chloro-5-hydroxyiminomethylnitrobenzene

Downstream raw materials:

C₂₃H₁₄Cl₃F₃N₂O₂

tert-butyl {2-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbamate

5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-chlorophenylhydrazine

N′-{5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-chlorophenyl}-4,4,4-trifluorobutyrohydrazide