(2R)-methyl 2-methoxycarbonylamino-2-methyl-3-phenylpropanoate

Base Information

• Chemical Name: (2R)-methyl 2-methoxycarbonylamino-2-methyl-3-phenylpropanoate
• CAS No.: 157718-86-0
• Molecular Formula: C₁₃H₁₇NO₄
• Molecular Weight: 251.282
• Mol file: 157718-86-0.mol

Synonyms:(2R)-methyl 2-methoxycarbonylamino-2-methyl-3-phenylpropanoate

Chemical Property of (2R)-methyl 2-methoxycarbonylamino-2-methyl-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-methyl 2-methoxycarbonylamino-2-methyl-3-phenylpropanoate

There total 4 articles about (2R)-methyl 2-methoxycarbonylamino-2-methyl-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanol (67-56-1) + (2S)-methyl 2-carbamoyl-2-methyl-3-phenylpropanoate (28052-47-3) → (2R)-methyl 2-methoxycarbonylamino-2-methyl-3-phenylpropanoate (157718-86-0)

Guidance literature:

With N-Bromosuccinimide; mercury(II) diacetate; In N,N-dimethyl-formamide; for 12h; Ambient temperature;

DOI:10.1016/S0957-4166(00)86182-0

Reference yield:

(S)-(+)-2-cyano-2-methyl-3-phenylpropanoic acid (27771-05-7) → (2R)-methyl 2-methoxycarbonylamino-2-methyl-3-phenylpropanoate (157718-86-0)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. NaOH, 30percent aq. H₂O₂ / 12 h

2: diethyl ether

3: 98 percent / Hg(OAc)2, NBS / dimethylformamide / 12 h / Ambient temperature

With sodium hydroxide; N-Bromosuccinimide; mercury(II) diacetate; dihydrogen peroxide; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1016/S0957-4166(00)86182-0

Reference yield:

(2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-cyano-2-methyl-3-phenylpropanoate (143100-05-4) → (2R)-methyl 2-methoxycarbonylamino-2-methyl-3-phenylpropanoate (157718-86-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 93 percent / KOH / methanol / 5 h / Heating

2: aq. NaOH, 30percent aq. H₂O₂ / 12 h

3: diethyl ether

4: 98 percent / Hg(OAc)2, NBS / dimethylformamide / 12 h / Ambient temperature

With potassium hydroxide; sodium hydroxide; N-Bromosuccinimide; mercury(II) diacetate; dihydrogen peroxide; In methanol; diethyl ether; N,N-dimethyl-formamide;

DOI:10.1016/S0957-4166(00)86182-0

upstream raw materials:

methanol

(2S)-methyl 2-carbamoyl-2-methyl-3-phenylpropanoate

(S)-(+)-2-cyano-2-methyl-3-phenylpropanoic acid

(2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-cyano-2-methyl-3-phenylpropanoate

Downstream raw materials:

(R)-2-amino-2-methyl-3-phenylpropanoic acid