Technology Process of N-(2-bromo-6-(trifluoromethyl)phenyl)acetamide
There total 5 articles about N-(2-bromo-6-(trifluoromethyl)phenyl)acetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium diacetate;
In
dimethyl sulfoxide;
at 25 ℃;
for 20h;
Irradiation;
DOI:10.1039/c9cc01014a
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 81 percent / Br2 / acetic acid / 1.) 45 deg C, 2.5 h, 2.) reflux, 4.75 h
2: 56 percent / ZnCl2 / benzene / 32 h / Heating
3: 86 percent / SnCl2*2H2O / ethanol / 1.) reflux, 0.5 h, 2.) room temp., 13 h
4: 1.) NaNO2, 48percent HBF4, 2.) 50percent aq. H3PO2 / 1.) H2O, 0 deg C, 2.5 h, 2.) CHCl3, 24 h, room temp.
With
tetrafluoroboric acid; bromine; hypophosphorous acid; tin(ll) chloride; zinc(II) chloride; sodium nitrite;
In
ethanol; acetic acid; benzene;
DOI:10.1021/jo00162a005
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 56 percent / ZnCl2 / benzene / 32 h / Heating
2: 86 percent / SnCl2*2H2O / ethanol / 1.) reflux, 0.5 h, 2.) room temp., 13 h
3: 1.) NaNO2, 48percent HBF4, 2.) 50percent aq. H3PO2 / 1.) H2O, 0 deg C, 2.5 h, 2.) CHCl3, 24 h, room temp.
With
tetrafluoroboric acid; hypophosphorous acid; tin(ll) chloride; zinc(II) chloride; sodium nitrite;
In
ethanol; benzene;
DOI:10.1021/jo00162a005
