1-(1-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)ethanone

Base Information

Chemical Name:1-(1-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)ethanone
CAS No.:1438072-59-3
Molecular Formula:C₂₆H₂₉ClFN₅O₃
Molecular Weight:513.999
Hs Code.:

Synonyms:1-(1-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)ethanone

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Chemical Property of 1-(1-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)ethanone

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Technology Process of 1-(1-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)ethanone

There total 10 articles about 1-(1-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1438072-53-7
N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydropyrrolo[3.4-b]pyrrol-1(2H)-yl)propoxy)-7-methoxyquinazolin-4-amine

: 75-36-5
acetyl chloride

: 1438072-59-3
1-(1-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)ethanone

Guidance literature:: With triethylamine; at 0 ℃; for 2h;

Reference yield:

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 1438072-59-3
1-(1-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)ethanone

Guidance literature:: Multi-step reaction with 6 steps

1: isopropyl alcohol / 5 h / 88 °C

2: water; sodium hydroxide / methanol / 6 h / 20 °C

3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 6 h / 40 °C

4: potassium carbonate / N,N-dimethyl-formamide / 6 h / 80 °C

5: hydrogenchloride / ethyl acetate / 2 h / 20 °C

6: triethylamine / 2 h / 0 °C

With hydrogenchloride; water; potassium carbonate; triethylamine; potassium iodide; sodium hydroxide; In methanol; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1438080-49-9
tert-butyl 1-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3.4-b]pyrrole-5(1H)carboxylate

: 1438072-59-3
1-(1-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethyl acetate / 2 h / 20 °C

2: triethylamine / 2 h / 0 °C

With hydrogenchloride; triethylamine; In ethyl acetate;