4-(chloromethyl)-N-phenyl-1,3-thiazol-2-amine hydrochloride

Base Information

• Chemical Name: 4-(chloromethyl)-N-phenyl-1,3-thiazol-2-amine hydrochloride
• CAS No.: 41981-20-8
• Molecular Formula: C₁₀H₉ClN₂S*ClH
• Molecular Weight: 261.175
• Mol file: 41981-20-8.mol

Synonyms:41981-20-8;4-(chloromethyl)-N-phenyl-1,3-thiazol-2-amine hydrochloride;(4-Chloromethyl-thiazol-2-yl)-phenyl-amine hydrochloride;4-(chloromethyl)-N-phenyl-1,3-thiazol-2-amine;hydrochloride;AKOS008028874;SB37121;EN300-30089;G27641;Z57072018;F2145-0258;4-(chloromethyl)-N-phenyl-1,3-thiazol-2-aminehydrochloride

Chemical Property of 4-(chloromethyl)-N-phenyl-1,3-thiazol-2-amine hydrochloride

Chemical Property:

• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 259.9941749
• Heavy Atom Count: 15
• Complexity: 174

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)NC2=NC(=CS2)CCl.Cl

Technology Process of 4-(chloromethyl)-N-phenyl-1,3-thiazol-2-amine hydrochloride

There total 1 articles about 4-(chloromethyl)-N-phenyl-1,3-thiazol-2-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-Dichloroacetone (534-07-6) + monophenylthiourea (103-85-5) → (4-chloromethyl-thiazol-2-yl)-phenyl-amine; hydrochloride (41981-20-8)

Guidance literature:

In acetone; at 20 ℃;

DOI:10.1016/j.molstruc.2021.130629

Reference yield: 48.0%

(Z)-5-(4-hydroxyphenylmethylene)-2,4-thiazolidinedione (103788-60-9,154052-92-3) + (4-chloromethyl-thiazol-2-yl)-phenyl-amine; hydrochloride (41981-20-8) → (Z)-5-(4-hydroxybenzylidene)-3-((2-(phenylamino)thiazol-4-yl)methyl)thiazolidine-2,4-dione

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; regioselective reaction;

DOI:10.1016/j.molstruc.2021.130629

upstream raw materials:

1,3-Dichloroacetone

monophenylthiourea