Technology Process of 2-deuterio-N-methoxybenzamide
There total 6 articles about 2-deuterio-N-methoxybenzamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
water; ethyl acetate;
at 0 - 20 ℃;
DOI:10.1021/ja5072702
- Guidance literature:
-
With
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; sodium acetate;
In
d(4)-methanol;
at 22 ℃;
for 18h;
regioselective reaction;
Inert atmosphere;
Sealed tube;
DOI:10.1002/chem.201502785
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran; diethyl ether / 2 h / -78 °C / Inert atmosphere; Schlenk technique
1.2: 0.5 h / 20 °C / Inert atmosphere; Schlenk technique
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / 78 °C / Inert atmosphere; Schlenk technique
2.2: 0.17 h / -78 - 20 °C
3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere; Schlenk technique
4.1: potassium carbonate / water; ethyl acetate / 16 h / 0 - 20 °C / Inert atmosphere; Schlenk technique
With
n-butyllithium; oxalyl dichloride; isopropylmagnesium chloride; potassium carbonate; N,N-dimethyl-formamide;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; ethyl acetate;
DOI:10.1002/anie.201206890
