(+)-8-bromo-N-<(S)-α-methylbenzyl>-2(R)-propionamidotetralin

Base Information

Chemical Name:(+)-8-bromo-N-<(S)-α-methylbenzyl>-2(R)-propionamidotetralin
CAS No.:136925-04-7
Molecular Formula:C₂₁H₂₄BrNO
Molecular Weight:386.332
Hs Code.:

Synonyms:(+)-8-bromo-N-<(S)-α-methylbenzyl>-2(R)-propionamidotetralin

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-8-bromo-N-<(S)-α-methylbenzyl>-2(R)-propionamidotetralin

Chemical Property:

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Technology Process of (+)-8-bromo-N-<(S)-α-methylbenzyl>-2(R)-propionamidotetralin

There total 3 articles about (+)-8-bromo-N-<(S)-α-methylbenzyl>-2(R)-propionamidotetralin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 79-03-8
propionyl chloride

: 136924-89-5
(+)-(2R)-8-bromo-N-<(S)-α-methylbenzyl>-2-aminotetralin

: 136925-04-7
(+)-8-bromo-N-<(S)-α-methylbenzyl>-2(R)-propionamidotetralin

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1021/jm00067a003

Reference yield:

: 55116-09-1
2-bromophenylacetyl chloride

: 136925-04-7
(+)-8-bromo-N-<(S)-α-methylbenzyl>-2(R)-propionamidotetralin

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / AlCl₃ / CH₂Cl₂ / 1.25 h / -10 °C

2: 46 percent / AcOH, 4A molecular sieves, sodium cyanoborohydride / methanol; tetrahydrofuran / 3 h / 0 °C

3: 99 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

With aluminium trichloride; 4 A molecular sieve; sodium cyanoborohydride; acetic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00067a003

Reference yield:

: 117294-21-0
8-bromo-2-tetralone

: 136925-04-7
(+)-8-bromo-N-<(S)-α-methylbenzyl>-2(R)-propionamidotetralin

Guidance literature:: Multi-step reaction with 2 steps

1: 46 percent / AcOH, 4A molecular sieves, sodium cyanoborohydride / methanol; tetrahydrofuran / 3 h / 0 °C

2: 99 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

With 4 A molecular sieve; sodium cyanoborohydride; acetic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00067a003