tert-butyl 3-(5-(3,4-dimethoxyphenylcarbamoyl)-1H-indol-2-yl)propyl(methyl)carbamate

Base Information

Chemical Name:tert-butyl 3-(5-(3,4-dimethoxyphenylcarbamoyl)-1H-indol-2-yl)propyl(methyl)carbamate
CAS No.:1312304-16-7
Molecular Formula:C₂₆H₃₃N₃O₅
Molecular Weight:467.565
Hs Code.:

Synonyms:tert-butyl 3-(5-(3,4-dimethoxyphenylcarbamoyl)-1H-indol-2-yl)propyl(methyl)carbamate

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Chemical Property of tert-butyl 3-(5-(3,4-dimethoxyphenylcarbamoyl)-1H-indol-2-yl)propyl(methyl)carbamate

Chemical Property:

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Technology Process of tert-butyl 3-(5-(3,4-dimethoxyphenylcarbamoyl)-1H-indol-2-yl)propyl(methyl)carbamate

There total 8 articles about tert-butyl 3-(5-(3,4-dimethoxyphenylcarbamoyl)-1H-indol-2-yl)propyl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312304-15-6
{5-[2-amino-5-(3,4-dimethoxy-phenylcarbamoyl)-phenyl]-pent-4-ynyl}-methyl-carbamic acid tert-butyl ester

: 1312304-16-7
tert-butyl 3-(5-(3,4-dimethoxyphenylcarbamoyl)-1H-indol-2-yl)propyl(methyl)carbamate

Guidance literature:: Pd(PhCN)2Cl₂; In N,N-dimethyl-formamide; at 80 ℃; for 24h;

Reference yield:

: 15252-44-5
1-amino-pent-4-yne

: 1312304-16-7
tert-butyl 3-(5-(3,4-dimethoxyphenylcarbamoyl)-1H-indol-2-yl)propyl(methyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 20 °C / Ice/water bath

2.1: sodium hydride / tetrahydrofuran / 20 °C / Ice/water bath

2.2: 72 h

3.1: diethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / 24 h / 20 °C

4.1: Pd(PhCN)2Cl₂ / N,N-dimethyl-formamide / 24 h / 80 °C

With sodium hydride; diethylamine; triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Pd(PhCN)2Cl₂; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 2122-63-6
4-amino-3-iodobenzoic acid

: 1312304-16-7
tert-butyl 3-(5-(3,4-dimethoxyphenylcarbamoyl)-1H-indol-2-yl)propyl(methyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / dichloromethane / 24 h / 20 °C

2: diethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / 24 h / 20 °C

3: Pd(PhCN)2Cl₂ / N,N-dimethyl-formamide / 24 h / 80 °C

With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; diethylamine; triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Pd(PhCN)2Cl₂; In dichloromethane; N,N-dimethyl-formamide;