(4-{2-[4-Benzyl-5-(2,2-dimethyl-propoxycarbonylamino)-oxazol-2-yl]-1-phenyl-ethoxy}-phenyl)-acetic acid isopropyl ester

Base Information

Chemical Name:(4-{2-[4-Benzyl-5-(2,2-dimethyl-propoxycarbonylamino)-oxazol-2-yl]-1-phenyl-ethoxy}-phenyl)-acetic acid isopropyl ester
CAS No.:127086-96-8
Molecular Formula:C₃₅H₄₀N₂O₆
Molecular Weight:584.712
Hs Code.:

Synonyms:(4-{2-[4-Benzyl-5-(2,2-dimethyl-propoxycarbonylamino)-oxazol-2-yl]-1-phenyl-ethoxy}-phenyl)-acetic acid isopropyl ester

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Chemical Property of (4-{2-[4-Benzyl-5-(2,2-dimethyl-propoxycarbonylamino)-oxazol-2-yl]-1-phenyl-ethoxy}-phenyl)-acetic acid isopropyl ester

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Technology Process of (4-{2-[4-Benzyl-5-(2,2-dimethyl-propoxycarbonylamino)-oxazol-2-yl]-1-phenyl-ethoxy}-phenyl)-acetic acid isopropyl ester

There total 10 articles about (4-{2-[4-Benzyl-5-(2,2-dimethyl-propoxycarbonylamino)-oxazol-2-yl]-1-phenyl-ethoxy}-phenyl)-acetic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 34619-03-9
tert-butyldicarbonate

: 127086-79-7
2-<2-phenyl-2-<4-<(isopropoxycarbonyl)methyl>phenoxy>ethyl>-4-benzyl-5-(trifluoroacetamido)oxazole

: 127086-96-8
(4-{2-[4-Benzyl-5-(2,2-dimethyl-propoxycarbonylamino)-oxazol-2-yl]-1-phenyl-ethoxy}-phenyl)-acetic acid isopropyl ester

Guidance literature:: With 4-methyl-morpholine; In dichloromethane; at 0 ℃; for 4h;
DOI:10.1021/ja00175a039

Reference yield:

: 156-38-7
4-hydroxyphenylacetate

: 127086-96-8
(4-{2-[4-Benzyl-5-(2,2-dimethyl-propoxycarbonylamino)-oxazol-2-yl]-1-phenyl-ethoxy}-phenyl)-acetic acid isopropyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / conc. H₂SO₄ / Heating

2: 1.) KH, 2.) 18-crown-6 / 1.) THF, RT, 20 min, 2.) RT

3: 98 percent / H₂, / 10percent Pd/C / ethyl acetate / 3 h

4: 99.8 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 0 °C

5: 1.) 1,3-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole hydrate / 1.) CHCl₃, 0 deg C, 15 min, 2.) 0 deg C to RT

6: 84 percent / trifluoroacetic acid / CH₂Cl₂ / 5 h / 0 °C

7: 87 percent / N-methylmorpholine / CH₂Cl₂ / 4 h / 0 °C

With 4-methyl-morpholine; 18-crown-6 ether; sulfuric acid; hydrogen; potassium hydride; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/ja00175a039

Reference yield:

: 41997-33-5
iso-propyl 4-hydroxyphenylacetate

: 127086-96-8
(4-{2-[4-Benzyl-5-(2,2-dimethyl-propoxycarbonylamino)-oxazol-2-yl]-1-phenyl-ethoxy}-phenyl)-acetic acid isopropyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) KH, 2.) 18-crown-6 / 1.) THF, RT, 20 min, 2.) RT

2: 98 percent / H₂, / 10percent Pd/C / ethyl acetate / 3 h

3: 99.8 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 0 °C

4: 1.) 1,3-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole hydrate / 1.) CHCl₃, 0 deg C, 15 min, 2.) 0 deg C to RT

5: 84 percent / trifluoroacetic acid / CH₂Cl₂ / 5 h / 0 °C

6: 87 percent / N-methylmorpholine / CH₂Cl₂ / 4 h / 0 °C

With 4-methyl-morpholine; 18-crown-6 ether; hydrogen; potassium hydride; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/ja00175a039