4-Nitro-benzenesulfonic acid 2-{4-[2-(4-benzyl-5-tert-butoxycarbonylamino-oxazol-2-yl)-1-phenyl-ethoxy]-phenyl}-ethyl ester

Base Information

Chemical Name:4-Nitro-benzenesulfonic acid 2-{4-[2-(4-benzyl-5-tert-butoxycarbonylamino-oxazol-2-yl)-1-phenyl-ethoxy]-phenyl}-ethyl ester
CAS No.:127087-05-2
Molecular Formula:C₃₇H₃₇N₃O₉S
Molecular Weight:699.781
Hs Code.:

Synonyms:4-Nitro-benzenesulfonic acid 2-{4-[2-(4-benzyl-5-tert-butoxycarbonylamino-oxazol-2-yl)-1-phenyl-ethoxy]-phenyl}-ethyl ester

Suppliers and Price of 4-Nitro-benzenesulfonic acid 2-{4-[2-(4-benzyl-5-tert-butoxycarbonylamino-oxazol-2-yl)-1-phenyl-ethoxy]-phenyl}-ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-Nitro-benzenesulfonic acid 2-{4-[2-(4-benzyl-5-tert-butoxycarbonylamino-oxazol-2-yl)-1-phenyl-ethoxy]-phenyl}-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-Nitro-benzenesulfonic acid 2-{4-[2-(4-benzyl-5-tert-butoxycarbonylamino-oxazol-2-yl)-1-phenyl-ethoxy]-phenyl}-ethyl ester

There total 12 articles about 4-Nitro-benzenesulfonic acid 2-{4-[2-(4-benzyl-5-tert-butoxycarbonylamino-oxazol-2-yl)-1-phenyl-ethoxy]-phenyl}-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 156-38-7
4-hydroxyphenylacetate

: 127087-05-2
4-Nitro-benzenesulfonic acid 2-{4-[2-(4-benzyl-5-tert-butoxycarbonylamino-oxazol-2-yl)-1-phenyl-ethoxy]-phenyl}-ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 97 percent / conc. H₂SO₄ / Heating

2: 1.) KH, 2.) 18-crown-6 / 1.) THF, RT, 20 min, 2.) RT

3: 98 percent / H₂, / 10percent Pd/C / ethyl acetate / 3 h

4: 99.8 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 0 °C

5: 1.) 1,3-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole hydrate / 1.) CHCl₃, 0 deg C, 15 min, 2.) 0 deg C to RT

6: 84 percent / trifluoroacetic acid / CH₂Cl₂ / 5 h / 0 °C

7: 87 percent / N-methylmorpholine / CH₂Cl₂ / 4 h / 0 °C

8: LiAlH₄ / tetrahydrofuran / 0.25 h / 0 °C

9: pyridine / CH₂Cl₂ / 4 h / 0 °C

With 4-methyl-morpholine; pyridine; lithium aluminium tetrahydride; 18-crown-6 ether; sulfuric acid; hydrogen; potassium hydride; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/ja00175a039

Reference yield:

: 41997-33-5
iso-propyl 4-hydroxyphenylacetate

: 127087-05-2
4-Nitro-benzenesulfonic acid 2-{4-[2-(4-benzyl-5-tert-butoxycarbonylamino-oxazol-2-yl)-1-phenyl-ethoxy]-phenyl}-ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) KH, 2.) 18-crown-6 / 1.) THF, RT, 20 min, 2.) RT

2: 98 percent / H₂, / 10percent Pd/C / ethyl acetate / 3 h

3: 99.8 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 0 °C

4: 1.) 1,3-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole hydrate / 1.) CHCl₃, 0 deg C, 15 min, 2.) 0 deg C to RT

5: 84 percent / trifluoroacetic acid / CH₂Cl₂ / 5 h / 0 °C

6: 87 percent / N-methylmorpholine / CH₂Cl₂ / 4 h / 0 °C

7: LiAlH₄ / tetrahydrofuran / 0.25 h / 0 °C

8: pyridine / CH₂Cl₂ / 4 h / 0 °C

With 4-methyl-morpholine; pyridine; lithium aluminium tetrahydride; 18-crown-6 ether; hydrogen; potassium hydride; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/ja00175a039

Reference yield:

: 93139-50-5
3-phenylpropionic acid tert-butyl ester

: 127087-05-2
4-Nitro-benzenesulfonic acid 2-{4-[2-(4-benzyl-5-tert-butoxycarbonylamino-oxazol-2-yl)-1-phenyl-ethoxy]-phenyl}-ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) KH, 2.) 18-crown-6 / 1.) THF, RT, 20 min, 2.) RT

2: 98 percent / H₂, / 10percent Pd/C / ethyl acetate / 3 h

3: 99.8 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 0 °C

4: 1.) 1,3-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole hydrate / 1.) CHCl₃, 0 deg C, 15 min, 2.) 0 deg C to RT

5: 84 percent / trifluoroacetic acid / CH₂Cl₂ / 5 h / 0 °C

6: 87 percent / N-methylmorpholine / CH₂Cl₂ / 4 h / 0 °C

7: LiAlH₄ / tetrahydrofuran / 0.25 h / 0 °C

8: pyridine / CH₂Cl₂ / 4 h / 0 °C

With 4-methyl-morpholine; pyridine; lithium aluminium tetrahydride; 18-crown-6 ether; hydrogen; potassium hydride; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/ja00175a039