(R)-2-(m-methoxyphenyl)-2-methylmalonic monoester

Base Information

Chemical Name:(R)-2-(m-methoxyphenyl)-2-methylmalonic monoester
CAS No.:178681-54-4
Molecular Formula:C₁₃H₁₆O₅
Molecular Weight:252.267
Hs Code.:

Synonyms:(R)-2-(m-methoxyphenyl)-2-methylmalonic monoester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-(m-methoxyphenyl)-2-methylmalonic monoester

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Technology Process of (R)-2-(m-methoxyphenyl)-2-methylmalonic monoester

There total 3 articles about (R)-2-(m-methoxyphenyl)-2-methylmalonic monoester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 83026-48-6
diethyl (3-methoxyphenyl)methylpropanedioate

: 178681-54-4
(R)-2-(m-methoxyphenyl)-2-methylmalonic monoester

Guidance literature:: With pH 8.04 phosphate buffer; In acetone; for 10h; Ambient temperature;
DOI:10.3987/COM-96-7421

Reference yield:

: 50874-07-2
2-(3-methoxyphenyl)malonic acid diethyl ester

: 178681-54-4
(R)-2-(m-methoxyphenyl)-2-methylmalonic monoester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / 1.) NaH / paraffin; 1,2-dimethoxy-ethane / 18 h / Ambient temperature; 1.) room temp., 40 min

2: 70 percent / PLE, pH 8.04 phosphate buffer / acetone / 10 h / Ambient temperature

With pH 8.04 phosphate buffer; sodium hydride; In 1,2-dimethoxyethane; acetone; paraffin;
DOI:10.3987/COM-96-7421

Reference yield:

: 35553-92-5
ETHYL 3-METHOXYPHENYLACETATE

: 178681-54-4
(R)-2-(m-methoxyphenyl)-2-methylmalonic monoester

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / NaH / benzene; paraffin / 2.5 h / Heating

2: 90 percent / 1.) NaH / paraffin; 1,2-dimethoxy-ethane / 18 h / Ambient temperature; 1.) room temp., 40 min

3: 70 percent / PLE, pH 8.04 phosphate buffer / acetone / 10 h / Ambient temperature

With pH 8.04 phosphate buffer; sodium hydride; In 1,2-dimethoxyethane; acetone; paraffin; benzene;
DOI:10.3987/COM-96-7421