4-chloro-2-(2,6-dichloro-4-vinyl-phenyl)-thiazolo[5,4-c]pyridine

Base Information

Chemical Name:4-chloro-2-(2,6-dichloro-4-vinyl-phenyl)-thiazolo[5,4-c]pyridine
CAS No.:1365992-11-5
Molecular Formula:C₁₄H₇Cl₃N₂S
Molecular Weight:341.648
Hs Code.:

Synonyms:4-chloro-2-(2,6-dichloro-4-vinyl-phenyl)-thiazolo[5,4-c]pyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-chloro-2-(2,6-dichloro-4-vinyl-phenyl)-thiazolo[5,4-c]pyridine

Chemical Property:

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Technology Process of 4-chloro-2-(2,6-dichloro-4-vinyl-phenyl)-thiazolo[5,4-c]pyridine

There total 8 articles about 4-chloro-2-(2,6-dichloro-4-vinyl-phenyl)-thiazolo[5,4-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1365992-10-4
4-chloro-2-(2,6-dichloro-4-iodo-phenyl)-thiazolo[5,4-c]pyridine

: 75927-49-0
pinacol vinylboronate

: 1365992-11-5
4-chloro-2-(2,6-dichloro-4-vinyl-phenyl)-thiazolo[5,4-c]pyridine

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; water; at 100 ℃; for 2h; Inert atmosphere;

Reference yield:

: 628691-93-0
2-chloro-3-fluoro-pyridine-4-carboxylic acid

: 1365992-11-5
4-chloro-2-(2,6-dichloro-4-vinyl-phenyl)-thiazolo[5,4-c]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: diphenyl phosphoryl azide / toluene / 3 h / 110 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

2.2: NH₂ cartridge

3.1: triethylamine / 1,4-dioxane / 18 h / 100 °C

4.1: thionyl chloride / 56 h / 90 °C

5.1: thiourea; pyridine / isopropyl alcohol / 3.5 h / 90 °C

5.2: 1.5 h / 90 °C

6.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

With pyridine; thionyl chloride; diphenyl phosphoryl azide; sodium carbonate; triethylamine; thiourea; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; dichloromethane; water; isopropyl alcohol; toluene;

Reference yield:

: 1258298-01-9
2,6-dichloro-4-iodo-benzoic acid

: 1365992-11-5
4-chloro-2-(2,6-dichloro-4-vinyl-phenyl)-thiazolo[5,4-c]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 2 h / Reflux

2.1: triethylamine / 1,4-dioxane / 18 h / 100 °C

3.1: thionyl chloride / 56 h / 90 °C

4.1: thiourea; pyridine / isopropyl alcohol / 3.5 h / 90 °C

4.2: 1.5 h / 90 °C

5.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

With pyridine; thionyl chloride; sodium carbonate; triethylamine; thiourea; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; water; isopropyl alcohol;