2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl methanesulfonate

Base Information

• Chemical Name: 2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl methanesulfonate
• CAS No.: 1190927-36-6
• Molecular Formula: C₁₅H₁₄N₂O₄S₂
• Molecular Weight: 350.419

Synonyms:2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl methanesulfonate

Chemical Property of 2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl methanesulfonate

Chemical Property:

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Technology Process of 2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl methanesulfonate

There total 1 articles about 2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethanol (1190927-35-5) + Methanesulfonic anhydride (7143-01-3) → 2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl methanesulfonate (1190927-36-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; dmap; In dichloromethane; at 20 ℃; Cooling;

Reference yield: 23.0%

4-carboxamidopiperidine (39546-32-2) + 2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl methanesulfonate (1190927-36-6) → 1-{2-[4-([1,3]Thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl}piperidine-4-carboxamide (1190924-88-9)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 50 ℃;

DOI:10.1016/j.bmcl.2012.10.036

Reference yield: 22.0%

2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl methanesulfonate (1190927-36-6) + 1-(piperidin-4-yl)pyrrolidin-2-one (91596-61-1) → 1-(1-{2-[4-([1,3]Thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl}piperidin-4-yl)pyrrolidin-2-one (1190924-67-4)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 50 ℃;

DOI:10.1016/j.bmcl.2012.10.036

upstream raw materials:

2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethanol

Methanesulfonic anhydride

Downstream raw materials:

C₂₂H₂₅N₃O₃S

2-[4-(2-Piperidin-1-ylethyl)phenoxy][1,3]thiazolo[4,5-b]pyridine

1-{2-[4-([1,3]Thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl}piperidine-4-carboxamide

1-(1-{2-[4-([1,3]Thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl}piperidin-4-yl)pyrrolidin-2-one

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