hydrochloride of amide of glycylglycyl-L-phenylalanyl-L-leucine

Base Information

• Chemical Name: hydrochloride of amide of glycylglycyl-L-phenylalanyl-L-leucine
• CAS No.: 81638-87-1
• Molecular Formula: C₁₉H₂₉N₅O₄*ClH
• Molecular Weight: 427.931
• Mol file: 81638-87-1.mol

Synonyms:hydrochloride of amide of glycylglycyl-L-phenylalanyl-L-leucine

Chemical Property of hydrochloride of amide of glycylglycyl-L-phenylalanyl-L-leucine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of hydrochloride of amide of glycylglycyl-L-phenylalanyl-L-leucine

There total 9 articles about hydrochloride of amide of glycylglycyl-L-phenylalanyl-L-leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-((S)-2-amino-3-phenylpropanamido)-4-methylpentanamide hydrochloride (81638-86-0) → hydrochloride of amide of glycylglycyl-L-phenylalanyl-L-leucine (81638-87-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NH₃, 2.) AcOH / 1.) THF, CHCl₃, 2.) THF, 24 h

2: 98 percent / 2 M HCl / acetic acid / 0.75 h

With hydrogenchloride; ammonia; acetic acid; In acetic acid;

Reference yield:

tert-butyl ((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (74257-73-1) → hydrochloride of amide of glycylglycyl-L-phenylalanyl-L-leucine (81638-87-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / 2 M HCl / acetic acid / 0.75 h

2: 1.) NH₃, 2.) AcOH / 1.) THF, CHCl₃, 2.) THF, 24 h

3: 98 percent / 2 M HCl / acetic acid / 0.75 h

With hydrogenchloride; ammonia; acetic acid; In acetic acid;

Reference yield:

Boc-Gly-Phe-Leu-NH2 (93200-07-8,93200-08-9) → hydrochloride of amide of glycylglycyl-L-phenylalanyl-L-leucine (81638-87-1)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / 1 h / 20 °C

2: 4-methyl-morpholine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / water / 12 h / 20 °C

3: trifluoroacetic acid / 1 h / 20 °C

With 4-methyl-morpholine; trifluoroacetic acid; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In water;

DOI:10.1002/psc.1367

upstream raw materials:

H-L-Leu-NH₂

(S)-2-((S)-2-amino-3-phenylpropanamido)-4-methylpentanamide hydrochloride

tert-butyl ((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

O-(t-butyloxycarbonyl-L-phenylalanyl)-2-pyridylmethylketoxime

Downstream raw materials:

Boc-Tyr(tBu)-Gly-Gly-Phe-Leu-NH₂

trans-4-(3-hydroxyphenyl)-4-methylpipecolylglycylglycylphenylalanylleucinamide hydrochloride

cis-4-(3-hydroxyphenyl)-4-methylpipecolylglycylglycylphenylalanylleucinamide hydrochloride

amide of N-t-butyloxycarbonyl-β-alanyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine