82948-92-3

Upstream product

• 687-51-4 H-L-Leu-NH₂ 
• 74257-73-1 tert-butyl ((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate 
• 93200-07-8 Boc-Gly-Phe-Leu-NH₂ 
• 81638-86-0 (S)-2-((S)-2-amino-3-phenylpropanamido)-4-methylpentanamide hydrochloride 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 71591-20-3 H-Gly-Phe-Leu-NH₂ 
• 38678-59-0 L-Phe-L-Leu-NH₂ 
• 35909-92-3 N-carbobenzoxy-L-phenylalanine methyl ester 
• 69193-15-3 N-(benzyloxycarbonyl)-glycyl-L-phenylalanyl-L-leucine amide 
• 69193-13-1 Cbz-L-Phe-L-Leu-NH₂ 
• 169676-30-6 Z-Gly-Gly-L-Phe-OCH₂CF₃ 
• 10466-61-2 (2S)-amino-4-methylpentanamide hydrochloride 
• 15027-03-9 Z-Gly-Gly-L-Phe-OMe 
• 75286-46-3 amide of N-t-butyloxycarbonylglycylglycyl-L-phenylalanyl-L-leucine 

Downstream Products

• 79396-86-4 Boc-L-Tyr-Gly-Gly-L-Phe-L-Leu-NH₂ 
• 217792-91-1 2,2-dimethyl-thiopropionic acid S-(2-{[4-(2-amino-2-{[({[1-(1-carbamoyl-3-methyl-butylcarbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-methyl]-carbamoyl}-ethyl)-phenoxy]-[2-(2,2-dimethyl-propionylsulfanyl)-ethoxy]-phosphoryloxy}-ethyl) ester 
• 75286-46-3 amide of N-t-butyloxycarbonylglycylglycyl-L-phenylalanyl-L-leucine 
• 1313481-74-1 Boc-Tyr(tBu)-Gly-Gly-Phe-Leu-NH₂ 
• 81638-87-1 hydrochloride of amide of glycylglycyl-L-phenylalanyl-L-leucine 
• 81638-88-2 amide of N-t-butyloxycarbonyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine 
• 71591-21-4 Z-Tyr-Gly-Gly-Phe-Leu-NH₂ 

Relevant academic research and scientific papers

Peptide synthesis 'in water' by a solution-phase method using water-dispersible nanoparticle Boc-amino acid

Regulatory pressure has compelled the chemical manufacturing industry to reduce the use of organic solvents in synthetic chemistry, and there is currently a strong focus on replacing these solvents with water. Here, we describe an efficient in-water solution-phase peptide synthesis method using Boc-amino acids. It is based on a coupling reaction utilizing suspended water-dispersible nanoparticle reactants. Using this method, peptides were obtained in good yield and with high purity.

α-chymotrypsin-catalysed segment condensations via the kinetically controlled approach using carbamoylmethyl esters as acyl donors in organic media

The superiority of the carbamoylmethyl ester as an acyl donor for the α-chymotrypsin-catalysed segment condensations via the kinetically controlled approach is demonstrated in several model systems carried out in organic media with low water content. Furthermore, this approach is successfully applied to the construction of the Leu-enkephalin sequence via a 4 + 1 segment coupling.

Papain Catalysed Peptide Synthesis: Control of Amidase Activity and the Introduction of Unusual Amino Acids

Procedures for the papain catalysed synthesis of peptides containing D-amino acids and derivatives with control of the enzyme's amidase activity have been developed.