(2S,3R,5R,6S)-3-Benzoyloxymethyl-6-bromo-3-methyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl ester

Base Information

Chemical Name:(2S,3R,5R,6S)-3-Benzoyloxymethyl-6-bromo-3-methyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl ester
CAS No.:95122-90-0
Molecular Formula:C₂₂H₁₉BrN₂O₇S
Molecular Weight:535.372
Hs Code.:

Synonyms:(2S,3R,5R,6S)-3-Benzoyloxymethyl-6-bromo-3-methyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl ester

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Chemical Property of (2S,3R,5R,6S)-3-Benzoyloxymethyl-6-bromo-3-methyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl ester

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Technology Process of (2S,3R,5R,6S)-3-Benzoyloxymethyl-6-bromo-3-methyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl ester

There total 2 articles about (2S,3R,5R,6S)-3-Benzoyloxymethyl-6-bromo-3-methyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79634-01-8
p-nitrobenzoyl 6α-bromopenicillanate 1-oxide

: 95122-90-0
(2S,3R,5R,6S)-3-Benzoyloxymethyl-6-bromo-3-methyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / dioxane / 3.5 h / Heating

2: 1.) iodine / 1.) benzene, 1 h, 2.) benzene, CH₂Cl₂, 23 deg C, 4 h

With iodine; In 1,4-dioxane;
DOI:10.1021/jm00382a025

Reference yield:

: 532-31-0
silver benzoate

: 95122-89-7
p-nitrobenzyl 2-<2-oxo-3α-bromo-4-(benzothiazol-2-yldithio)azetidin-1-yl>-2-isopropenylacetate

: 95122-90-0
(2S,3R,5R,6S)-3-Benzoyloxymethyl-6-bromo-3-methyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl ester

: (2R,6R,7S)-3-Benzoyloxy-7-bromo-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid 4-nitro-benzyl ester

Guidance literature:: With iodine; Multistep reaction; 1.) benzene, 1 h, 2.) benzene, CH₂Cl₂, 23 deg C, 4 h;
DOI:10.1021/jm00382a025

Reference yield:

: 95122-90-0
(2S,3R,5R,6S)-3-Benzoyloxymethyl-6-bromo-3-methyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl ester

: (2S,3R,5R)-3-Benzoyloxymethyl-3-methyl-4,4,7-trioxo-4λ⁶-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid, KMNO₄, 30percent H₂O₂ / H₂O

2: H₂, NaHCO₃ / 10percent Pd/C / ethyl acetate / 3.5 h / 20 °C / 2585.7 Torr

With potassium permanganate; hydrogen; dihydrogen peroxide; sodium hydrogencarbonate; acetic acid; palladium on activated charcoal; In water; ethyl acetate;
DOI:10.1021/jm00382a025