[4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]-methyloxyacetic acid

Base Information

Chemical Name:[4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]-methyloxyacetic acid
CAS No.:181697-09-6
Molecular Formula:C₂₄H₂₂N₂O₆S
Molecular Weight:466.514
Hs Code.:

Synonyms:[4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]-methyloxyacetic acid

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Chemical Property of [4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]-methyloxyacetic acid

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Technology Process of [4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]-methyloxyacetic acid

There total 7 articles about [4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]-methyloxyacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: C₂₄H₂₄N₂O₇S

: 181697-09-6
[4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]-methyloxyacetic acid

Guidance literature:: With sulfuric acid; In tetrahydrofuran; for 1h; Heating / reflux;

Reference yield:

: 181697-07-4
2-[4-[N-[2,5-dimethylpyrrol]-sulfonyl]phenyl]-1-phenyl-ethan-1-one oxime

: 181697-09-6
[4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]-methyloxyacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1.17 h / -78 - 0 °C / Cooling with dry ice

1.2: 2 h / -78 - 20 °C

2.1: sulfuric acid / tetrahydrofuran / 1 h / Heating / reflux

With sulfuric acid; lithium diisopropyl amide; In tetrahydrofuran;

Reference yield:

: 451-40-1
phenyl benzyl ketone

: 181697-09-6
[4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]-methyloxyacetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: chlorosulfonic acid / 14 h / 5 - 20 °C

2.1: ammonia / water; acetone

3.1: thionyl chloride / ethanol / 0.5 h / Heating / reflux

4.1: hydroxylamine hydrochloride; sodium acetate / 14 h / Heating / reflux

5.1: lithium diisopropyl amide / tetrahydrofuran / 1.17 h / -78 - 0 °C / Cooling with dry ice

5.2: 2 h / -78 - 20 °C

6.1: sulfuric acid / tetrahydrofuran / 1 h / Heating / reflux

With chlorosulfonic acid; thionyl chloride; sulfuric acid; hydroxylamine hydrochloride; ammonia; sodium acetate; lithium diisopropyl amide; In tetrahydrofuran; ethanol; water; acetone;