(6S,E)-benzyl 6-((tert-butoxycarbonyl)amino)-6-(4-(4-((methoxycarbonyl)amino)-2-(2,2,2-trifluoroacetamido)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)-2-methylhex-3-enoate

Base Information

Chemical Name:(6S,E)-benzyl 6-((tert-butoxycarbonyl)amino)-6-(4-(4-((methoxycarbonyl)amino)-2-(2,2,2-trifluoroacetamido)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)-2-methylhex-3-enoate
CAS No.:1329169-68-7
Molecular Formula:C₃₈H₅₀F₃N₅O₈Si
Molecular Weight:789.924
Hs Code.:

(6S,E)-benzyl 6-((tert-butoxycarbonyl)amino)-6-(4-(4-((methoxycarbonyl)amino)-2-(2,2,2-trifluoroacetamido)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)-2-methylhex-3-enoate

Synonyms:(6S,E)-benzyl 6-((tert-butoxycarbonyl)amino)-6-(4-(4-((methoxycarbonyl)amino)-2-(2,2,2-trifluoroacetamido)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)-2-methylhex-3-enoate

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Chemical Property of (6S,E)-benzyl 6-((tert-butoxycarbonyl)amino)-6-(4-(4-((methoxycarbonyl)amino)-2-(2,2,2-trifluoroacetamido)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)-2-methylhex-3-enoate

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Technology Process of (6S,E)-benzyl 6-((tert-butoxycarbonyl)amino)-6-(4-(4-((methoxycarbonyl)amino)-2-(2,2,2-trifluoroacetamido)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)-2-methylhex-3-enoate

There total 8 articles about (6S,E)-benzyl 6-((tert-butoxycarbonyl)amino)-6-(4-(4-((methoxycarbonyl)amino)-2-(2,2,2-trifluoroacetamido)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)-2-methylhex-3-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1329169-67-6
methyl N-(4-(2-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-3-((trifluoroacetyl)amino)phenyl)carbamate

: 37526-85-5
benzyl 2-methylbut-3-enoate

: 1329169-68-7
(6S,E)-benzyl 6-((tert-butoxycarbonyl)amino)-6-(4-(4-((methoxycarbonyl)amino)-2-(2,2,2-trifluoroacetamido)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)-2-methylhex-3-enoate

Guidance literature:: methyl N-(4-(2-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-3-((trifluoroacetyl)amino)phenyl)carbamate; With toluene-4-sulfonic acid; In dichloromethane; at 40 ℃; for 1.16667h; Inert atmosphere;

benzyl 2-methylbut-3-enoate; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 40 ℃;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1329169-68-7
(6S,E)-benzyl 6-((tert-butoxycarbonyl)amino)-6-(4-(4-((methoxycarbonyl)amino)-2-(2,2,2-trifluoroacetamido)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)-2-methylhex-3-enoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Methyldicyclohexylamine / tetrahydrofuran / 20 h / 0 - 20 °C

2.1: potassium carbonate; ammonium hydroxide; L-proline; copper(l) iodide / dimethyl sulfoxide / 20 h / 85 °C / Inert atmosphere

3.1: triethylamine / ethyl acetate / 1 h / 0 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / dichloromethane / 1.17 h / 40 °C / Inert atmosphere

4.2: 40 °C

With ammonium hydroxide; copper(l) iodide; N-Methyldicyclohexylamine; potassium carbonate; toluene-4-sulfonic acid; triethylamine; L-proline; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 1329167-30-7
tert-butyl N-[(1S)-1-(4-{2-amino-4-[(methoxycarbonyl)-amino]phenyl}-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)but-3-en-1-yl]carbamate

: 1329169-68-7
(6S,E)-benzyl 6-((tert-butoxycarbonyl)amino)-6-(4-(4-((methoxycarbonyl)amino)-2-(2,2,2-trifluoroacetamido)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)-2-methylhex-3-enoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / ethyl acetate / 1 h / 0 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / dichloromethane / 1.17 h / 40 °C / Inert atmosphere

2.2: 40 °C

With toluene-4-sulfonic acid; triethylamine; In dichloromethane; ethyl acetate;