37526-85-5Relevant articles and documents
A concise and flexible synthesis of the core structure of pinnaic acid
Yang, Sung-Hyun,Caprio, Vittorio
, p. 1219 - 1222 (2007)
An efficient and flexible approach to the core structure of pinnaic acid has been developed that centres on the microwave-induced 1,3-dipolar cycloaddition of a novel spirocyclic nitrone 5 with alkene 7. The application of this nitrone to the synthesis of a diverse set of C5-substituted analogues of pinnaic acid is also demonstrated. Georg Thieme Verlag Stuttgart.
Cobalt-Bisoxazoline-Catalyzed Enantioselective Cross-Coupling of α-Bromo Esters with Alkenyl Grignard Reagents
Zhou, Yun,Wang, Lifeng,Yuan, Gucheng,Liu, Shikuo,Sun, Xiao,Yuan, Chaonan,Yang, Yuxiong,Bian, Qinghua,Wang, Min,Zhong, Jiangchun
supporting information, p. 4532 - 4536 (2020/06/05)
The first catalytic asymmetric Kumada cross-coupling of organic halides with alkenyl Grignard reagents has been developed. The reaction was promoted by the cobalt-bisoxazoline catalyst and afforded various α-alkyl-β,γ-unsaturated esters with excellent enantioselectivities and moderate to good yields (≤95% ee and ≤82% yields). The formal synthesis of the California red scale pheromone using this method was investigated, and radical clock experiments were performed.
CYCLIC P1 LINKERS AS FACTOR XIA INHIBITORS
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Paragraph 00314, (2013/03/26)
The present invention provides compounds of Formula (Ia): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.