N-(2-aminoethyl)-3-(2-(2,4-dichlorophenoxy)phenyl)thiophene-2-sulfonamide

Base Information

Chemical Name:N-(2-aminoethyl)-3-(2-(2,4-dichlorophenoxy)phenyl)thiophene-2-sulfonamide
CAS No.:1519044-08-6
Molecular Formula:C₁₈H₁₆Cl₂N₂O₃S₂
Molecular Weight:443.375
Hs Code.:

Synonyms:N-(2-aminoethyl)-3-(2-(2,4-dichlorophenoxy)phenyl)thiophene-2-sulfonamide

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Chemical Property of N-(2-aminoethyl)-3-(2-(2,4-dichlorophenoxy)phenyl)thiophene-2-sulfonamide

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Technology Process of N-(2-aminoethyl)-3-(2-(2,4-dichlorophenoxy)phenyl)thiophene-2-sulfonamide

There total 5 articles about N-(2-aminoethyl)-3-(2-(2,4-dichlorophenoxy)phenyl)thiophene-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1519044-07-5
tert-butyl 2-(3-(2-(2,4-dichlorophenoxy)phenyl)thiophene-2-sulfonamido)ethylcarbamate

: 1519044-08-6
N-(2-aminoethyl)-3-(2-(2,4-dichlorophenoxy)phenyl)thiophene-2-sulfonamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1002/cmdc.201400058

Reference yield:

: 26306-64-9
2,4-dichloro-1-(2-aminophenoxy)benzene

: 1519044-08-6
N-(2-aminoethyl)-3-(2-(2,4-dichlorophenoxy)phenyl)thiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid; sodium nitrite / water / 0.17 h / 0 - 5 °C

1.2: 4.5 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 3 h / -78 - 20 °C / Inert atmosphere

2.3: 20 °C

3.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate / tetrahydrofuran / 8 h / Inert atmosphere; Reflux

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; n-butyllithium; sulfuric acid; palladium diacetate; trifluoroacetic acid; sodium nitrite; In tetrahydrofuran; dichloromethane; water; 3.1: |Suzuki Coupling;
DOI:10.1002/cmdc.201400058

Reference yield:

: 175136-78-4
2,4-dichloro-1-(2-iodophenoxy)benzene

: 1519044-08-6
N-(2-aminoethyl)-3-(2-(2,4-dichlorophenoxy)phenyl)thiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 3 h / -78 - 20 °C / Inert atmosphere

1.3: 20 °C

2.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate / tetrahydrofuran / 8 h / Inert atmosphere; Reflux

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; n-butyllithium; palladium diacetate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 2.1: |Suzuki Coupling;
DOI:10.1002/cmdc.201400058