5-([1,4'-bipiperidin]-1'-yl)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile

Base Information

Chemical Name:5-([1,4'-bipiperidin]-1'-yl)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile
CAS No.:1616284-82-2
Molecular Formula:C₂₆H₄₁N₃O₂
Molecular Weight:427.63
Hs Code.:

Synonyms:5-([1,4'-bipiperidin]-1'-yl)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile

Suppliers and Price of 5-([1,4'-bipiperidin]-1'-yl)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-([1,4'-bipiperidin]-1'-yl)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-([1,4'-bipiperidin]-1'-yl)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile

There total 3 articles about 5-([1,4'-bipiperidin]-1'-yl)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 4897-50-1
4-piperidinopiperidin

: 27487-83-8
2-(3,4-dimethoxyphenyl)-2-isopropyl-2-(3-chloropropyl)acetonitrile

: 1616284-82-2
5-([1,4'-bipiperidin]-1'-yl)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 12h;
DOI:10.1016/j.bmcl.2014.05.022

Reference yield:

: 93-17-4
3,4-dimethoxyphenylacetonitrile

: 1616284-82-2
5-([1,4'-bipiperidin]-1'-yl)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 20 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere

2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 1.33 h / -78 - 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 80 °C

With n-butyllithium; potassium carbonate; diisopropylamine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.05.022

Reference yield:

: 20850-49-1
2-(3,4-dimethoxyphenyl)-3-methylbutyronitrile

: 1616284-82-2
5-([1,4'-bipiperidin]-1'-yl)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 1.33 h / -78 - 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 80 °C

With n-butyllithium; potassium carbonate; diisopropylamine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.05.022