Technology Process of ethyl 4-[3-bromo-5-fluoro-2-(methyloxy)phenyl]butanoate
There total 4 articles about ethyl 4-[3-bromo-5-fluoro-2-(methyloxy)phenyl]butanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: caesium carbonate; tri-tert-butyl phosphine / tris-(dibenzylideneacetone)dipalladium(0) / tetrahydrofuran / 20 °C / Inert atmosphere
2.1: ammonium chloride; iron / 90 °C
3.1: sodium nitrite; hydrogen bromide / acetonitrile; water / 0.17 h / 0 °C
3.2: 1 h / 50 °C
With
tri-tert-butyl phosphine; hydrogen bromide; iron; ammonium chloride; caesium carbonate; sodium nitrite;
tris-(dibenzylideneacetone)dipalladium(0);
In
tetrahydrofuran; water; acetonitrile;
- Guidance literature:
-
ethyl 4-[3-amino-5-fluoro-2-(methyloxy)phenyl]butanoate;
With
hydrogen bromide; sodium nitrite;
In
water; acetonitrile;
at 0 ℃;
for 0.166667h;
With
copper(ll) bromide;
copper(I) bromide;
In
water; acetonitrile;
at 50 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: nitric acid; sulfuric acid / 0.5 h / -10 °C
2.1: caesium carbonate; tri-tert-butyl phosphine / tris-(dibenzylideneacetone)dipalladium(0) / tetrahydrofuran / 20 °C / Inert atmosphere
3.1: ammonium chloride; iron / 90 °C
4.1: sodium nitrite; hydrogen bromide / acetonitrile; water / 0.17 h / 0 °C
4.2: 1 h / 50 °C
With
tri-tert-butyl phosphine; sulfuric acid; hydrogen bromide; nitric acid; iron; ammonium chloride; caesium carbonate; sodium nitrite;
tris-(dibenzylideneacetone)dipalladium(0);
In
tetrahydrofuran; water; acetonitrile;
