N-(2-((2-(2-methoxypropan-2-yl)oxazol-4-yl)methyl)-2H-1,2,3-triazol-4-yl)-5-phenyloxazole-4-carboxamide

Base Information

Chemical Name:N-(2-((2-(2-methoxypropan-2-yl)oxazol-4-yl)methyl)-2H-1,2,3-triazol-4-yl)-5-phenyloxazole-4-carboxamide
CAS No.:1381778-55-7
Molecular Formula:C₂₀H₂₀N₆O₄
Molecular Weight:408.417
Hs Code.:

Synonyms:N-(2-((2-(2-methoxypropan-2-yl)oxazol-4-yl)methyl)-2H-1,2,3-triazol-4-yl)-5-phenyloxazole-4-carboxamide

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Chemical Property of N-(2-((2-(2-methoxypropan-2-yl)oxazol-4-yl)methyl)-2H-1,2,3-triazol-4-yl)-5-phenyloxazole-4-carboxamide

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Technology Process of N-(2-((2-(2-methoxypropan-2-yl)oxazol-4-yl)methyl)-2H-1,2,3-triazol-4-yl)-5-phenyloxazole-4-carboxamide

There total 10 articles about N-(2-((2-(2-methoxypropan-2-yl)oxazol-4-yl)methyl)-2H-1,2,3-triazol-4-yl)-5-phenyloxazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1381778-82-0
2-((2-(2-methoxypropan-2-yl)oxazol-4-yl)methyl)-2H-1,2,3-triazol-4-amine

: 99924-18-2
5-phenyl-1,3-oxazole-4-carboxylic acid

: 1381778-55-7
N-(2-((2-(2-methoxypropan-2-yl)oxazol-4-yl)methyl)-2H-1,2,3-triazol-4-yl)-5-phenyloxazole-4-carboxamide

Guidance literature:: 5-phenyl-1,3-oxazole-4-carboxylic acid; With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.75h; Inert atmosphere;

2-((2-(2-methoxypropan-2-yl)oxazol-4-yl)methyl)-2H-1,2,3-triazol-4-amine; In dichloromethane; at 20 ℃;

Reference yield:

: 132629-37-9
ethyl 2-[(E)-2-phenylethenyl]oxazole-4-carboxylate

: 1381778-55-7
N-(2-((2-(2-methoxypropan-2-yl)oxazol-4-yl)methyl)-2H-1,2,3-triazol-4-yl)-5-phenyloxazole-4-carboxamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

1.2: 24 h / 20 °C

2.1: 1H-imidazole / dichloromethane; toluene / 1 h / 20 °C / Inert atmosphere

3.1: sodium periodate; silica gel / ruthenium(III) trichloride hydrate / dichloromethane / 20 °C / Darkness; Inert atmosphere

4.1: dichloromethane; toluene / 0.75 h / 0 °C / Inert atmosphere

5.1: manganese(IV) oxide / acetonitrile / 20 °C / Inert atmosphere

6.1: dichloromethane; toluene / 1.5 h / 0 °C / Inert atmosphere

7.1: silver(l) oxide / dichloromethane / 40 °C / Inert atmosphere; Darkness

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere

9.1: dmap; triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

10.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 50 °C

11.1: ammonium chloride; iron / ethanol; water / 0.5 h / 85 °C / Inert atmosphere

12.1: dmap; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

12.2: 20 °C

With 1H-imidazole; dmap; manganese(IV) oxide; sodium periodate; tetrabutyl ammonium fluoride; silica gel; iron; diisobutylaluminium hydride; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; silver(l) oxide; ruthenium(III) trichloride hydrate; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 107367-72-6
4-hydroxymethyl-2-((E)-2-phenyl-1-ethenyl)-1,3-oxazole

: 1381778-55-7
N-(2-((2-(2-methoxypropan-2-yl)oxazol-4-yl)methyl)-2H-1,2,3-triazol-4-yl)-5-phenyloxazole-4-carboxamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: 1H-imidazole / dichloromethane; toluene / 1 h / 20 °C / Inert atmosphere

2.1: sodium periodate; silica gel / ruthenium(III) trichloride hydrate / dichloromethane / 20 °C / Darkness; Inert atmosphere

3.1: dichloromethane; toluene / 0.75 h / 0 °C / Inert atmosphere

4.1: manganese(IV) oxide / acetonitrile / 20 °C / Inert atmosphere

5.1: dichloromethane; toluene / 1.5 h / 0 °C / Inert atmosphere

6.1: silver(l) oxide / dichloromethane / 40 °C / Inert atmosphere; Darkness

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere

8.1: dmap; triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

9.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 50 °C

10.1: ammonium chloride; iron / ethanol; water / 0.5 h / 85 °C / Inert atmosphere

11.1: dmap; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

11.2: 20 °C

With 1H-imidazole; dmap; manganese(IV) oxide; sodium periodate; tetrabutyl ammonium fluoride; silica gel; iron; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; silver(l) oxide; ruthenium(III) trichloride hydrate; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;