2-[3-amino-5-(4-isopropoxyphenyl)-1H-pyrazol-4-yl]-N,N-diethylacetamide

Base Information

• Chemical Name: 2-[3-amino-5-(4-isopropoxyphenyl)-1H-pyrazol-4-yl]-N,N-diethylacetamide
• CAS No.: 1384517-65-0
• Molecular Formula: C₁₈H₂₆N₄O₂
• Molecular Weight: 330.43

Synonyms:2-[3-amino-5-(4-isopropoxyphenyl)-1H-pyrazol-4-yl]-N,N-diethylacetamide

Chemical Property of 2-[3-amino-5-(4-isopropoxyphenyl)-1H-pyrazol-4-yl]-N,N-diethylacetamide

Chemical Property:

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Technology Process of 2-[3-amino-5-(4-isopropoxyphenyl)-1H-pyrazol-4-yl]-N,N-diethylacetamide

There total 10 articles about 2-[3-amino-5-(4-isopropoxyphenyl)-1H-pyrazol-4-yl]-N,N-diethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.2%

2-bromo-N,N-diethylacetamide (2430-01-5) + 3-(4-isopropoxyphenyl)-3-oxopropanenitrile (884504-22-7) → 2-[3-amino-5-(4-isopropoxyphenyl)-1H-pyrazol-4-yl]-N,N-diethylacetamide (1384517-65-0)

Guidance literature:

3-(4-isopropoxyphenyl)-3-oxopropanenitrile; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 1h;

2-bromo-N,N-diethylacetamide; In tetrahydrofuran; mineral oil;

With hydrazine hydrate; acetic acid; In ethanol; Reflux;

DOI:10.1016/j.ejmech.2018.09.069

Reference yield: 73.5%

3-cyano-N,N-diethyl-4-(4-isopropoxyphenyl)-4-oxobutanamide (1384517-64-9) → 2-[3-amino-5-(4-isopropoxyphenyl)-1H-pyrazol-4-yl]-N,N-diethylacetamide (1384517-65-0)

Guidance literature:

With hydrazine hydrate; acetic acid; In ethanol; at 100 ℃; for 4h;

Reference yield: 71.0%

2-bromo-N,N-diethylacetamide (2430-01-5) + 3-(4-isopropoxyphenyl)-3-oxopropanenitrile (884504-22-7) → 3-amino-5-(4-isopropoxyphenyl)-1H-pyrazole (208519-13-5) + 2-[3-amino-5-(4-isopropoxyphenyl)-1H-pyrazol-4-yl]-N,N-diethylacetamide (1384517-65-0)

Guidance literature:

3-(4-isopropoxyphenyl)-3-oxopropanenitrile; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere;

2-bromo-N,N-diethylacetamide; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere;

With hydrazine hydrate; acetic acid; In ethanol; for 13h; Inert atmosphere; Reflux;

DOI:10.1016/j.tetlet.2012.05.044

upstream raw materials:

2-bromo-N,N-diethylacetamide

3-(4-isopropoxyphenyl)-3-oxopropanenitrile

methyl 4-isopropoxybenzoate

methyl 4-hydroxylbenzoate

Downstream raw materials:

2-[2-(4'-hydroxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide

2-[5,7-dimethyl-2-(4-(prop-2-yn-1-yloxy)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide

2-[2-(4-isopropoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide

2-(2-(4-cyclobutoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide

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