1-(4-methoxy-phenyl)-5-(9H-purin-6-ylsulfanyl)-pentan-1-one

Base Information

• Chemical Name: 1-(4-methoxy-phenyl)-5-(9H-purin-6-ylsulfanyl)-pentan-1-one
• CAS No.: 276873-26-8
• Molecular Formula: C₁₇H₁₈N₄O₂S
• Molecular Weight: 342.422
• Mol file: 276873-26-8.mol

Synonyms:1-(4-methoxy-phenyl)-5-(9H-purin-6-ylsulfanyl)-pentan-1-one

Chemical Property of 1-(4-methoxy-phenyl)-5-(9H-purin-6-ylsulfanyl)-pentan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-methoxy-phenyl)-5-(9H-purin-6-ylsulfanyl)-pentan-1-one

There total 4 articles about 1-(4-methoxy-phenyl)-5-(9H-purin-6-ylsulfanyl)-pentan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

5-chloro-1-(4-methyloxyphenyl)pentan-1-one (949-06-4) + 6-mercaptopurine (50-44-2) → 1-(4-methoxy-phenyl)-5-(9H-purin-6-ylsulfanyl)-pentan-1-one (276873-26-8)

Guidance literature:

With potassium hydroxide; In ethanol; at 60 - 70 ℃;

DOI:10.1007/BF02323383

Reference yield:

5-Chlorovaleroyl chloride (1575-61-7) → 1-(4-methoxy-phenyl)-5-(9H-purin-6-ylsulfanyl)-pentan-1-one (276873-26-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / AlCl₃

2: 85 percent / 0.1 N KOH / ethanol / 60 - 70 °C

With potassium hydroxide; aluminium trichloride; In ethanol; 1: Acylation / 2: Substitution;

DOI:10.1007/BF02323383

Reference yield:

5-chloro-valeric acid (1119-46-6) → 1-(4-methoxy-phenyl)-5-(9H-purin-6-ylsulfanyl)-pentan-1-one (276873-26-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / SOCl₂ / dimethylformamide / 3 h / 75 °C

2: 69 percent / AlCl₃

3: 85 percent / 0.1 N KOH / ethanol / 60 - 70 °C

With potassium hydroxide; aluminium trichloride; thionyl chloride; In ethanol; N,N-dimethyl-formamide; 1: Substitution / 2: Acylation / 3: Substitution;

DOI:10.1007/BF02323383

upstream raw materials:

5-chloro-1-(4-methyloxyphenyl)pentan-1-one

6-mercaptopurine

5-Chlorovaleroyl chloride

5-chloro-valeric acid

Downstream raw materials:

hypoxanthine