3-((4-bromobenzyl)(ethyl)amino)-2-(4-fluorophenyl)quinazolin-4(3H)-one

Base Information

Chemical Name:3-((4-bromobenzyl)(ethyl)amino)-2-(4-fluorophenyl)quinazolin-4(3H)-one
CAS No.:1029982-40-8
Molecular Formula:C₂₃H₁₉BrFN₃O
Molecular Weight:452.326
Hs Code.:

Synonyms:3-((4-bromobenzyl)(ethyl)amino)-2-(4-fluorophenyl)quinazolin-4(3H)-one

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Chemical Property of 3-((4-bromobenzyl)(ethyl)amino)-2-(4-fluorophenyl)quinazolin-4(3H)-one

Chemical Property:

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Technology Process of 3-((4-bromobenzyl)(ethyl)amino)-2-(4-fluorophenyl)quinazolin-4(3H)-one

There total 5 articles about 3-((4-bromobenzyl)(ethyl)amino)-2-(4-fluorophenyl)quinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 389576-52-7
3-(4-bromobenzylamino)-2-(4-fluorophenyl)quinazolin-4(3H)-one

: 75-03-6
ethyl iodide

: 1029982-40-8
3-((4-bromobenzyl)(ethyl)amino)-2-(4-fluorophenyl)quinazolin-4(3H)-one

Guidance literature:: 3-(4-bromobenzylamino)-2-(4-fluorophenyl)quinazolin-4(3H)-one; With sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; oil; at 0 ℃; for 0.166667h;

ethyl iodide; In tetrahydrofuran; Oli; dimethyl sulfoxide; at 0 - 20 ℃; for 12h;

Reference yield:

: 403-43-0
4-fluorobenzoyl chloride

: 1029982-40-8
3-((4-bromobenzyl)(ethyl)amino)-2-(4-fluorophenyl)quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 0.17 h / 0 °C

1.2: 3 h / 0 - 20 °C

2.1: hydrazine / ethanol / 3 h / 80 °C

3.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

3.2: 12 h / 0 - 20 °C

4.1: dimethyl sulfoxide / tetrahydrofuran / 0.17 h / 0 °C

4.2: 0.17 h / 0 °C

4.3: 12 h / 0 - 20 °C

With pyridine; sodium hydride; hydrazine; dimethyl sulfoxide; In tetrahydrofuran; ethanol;

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 1029982-40-8
3-((4-bromobenzyl)(ethyl)amino)-2-(4-fluorophenyl)quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 0.17 h / 0 °C

1.2: 3 h / 0 - 20 °C

2.1: hydrazine / ethanol / 3 h / 80 °C

3.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

3.2: 12 h / 0 - 20 °C

4.1: dimethyl sulfoxide / tetrahydrofuran / 0.17 h / 0 °C

4.2: 0.17 h / 0 °C

4.3: 12 h / 0 - 20 °C

With pyridine; sodium hydride; hydrazine; dimethyl sulfoxide; In tetrahydrofuran; ethanol;