1-tert-butyl 4-ethyl 4-{[4-(phenylthio)phenyl]sulfonyl}piperidine-1,4-dicarboxylate

Base Information

Chemical Name:1-tert-butyl 4-ethyl 4-{[4-(phenylthio)phenyl]sulfonyl}piperidine-1,4-dicarboxylate
CAS No.:226397-38-2
Molecular Formula:C₂₅H₃₁NO₆S₂
Molecular Weight:505.656
Hs Code.:

Synonyms:1-tert-butyl 4-ethyl 4-{[4-(phenylthio)phenyl]sulfonyl}piperidine-1,4-dicarboxylate

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Chemical Property of 1-tert-butyl 4-ethyl 4-{[4-(phenylthio)phenyl]sulfonyl}piperidine-1,4-dicarboxylate

Chemical Property:

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Technology Process of 1-tert-butyl 4-ethyl 4-{[4-(phenylthio)phenyl]sulfonyl}piperidine-1,4-dicarboxylate

There total 4 articles about 1-tert-butyl 4-ethyl 4-{[4-(phenylthio)phenyl]sulfonyl}piperidine-1,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 226396-63-0
1-(tert-butyl) 4-ethyl 4-[(4-fluorophenyl)sulfonyl]piperidine-1,4-dicarboxylate

: 108-98-5
thiophenol

: 226397-38-2
1-tert-butyl 4-ethyl 4-{[4-(phenylthio)phenyl]sulfonyl}piperidine-1,4-dicarboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 36h;
DOI:10.1021/jm0500875

Reference yield:

: 226396-62-9
1-tert-butyl 4-ethyl 4-[(4-fluorophenyl)thio]piperidine-1,4-dicarboxylate

: 226397-38-2
1-tert-butyl 4-ethyl 4-{[4-(phenylthio)phenyl]sulfonyl}piperidine-1,4-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / MCPBA / CH₂Cl₂ / 20 h / 0 °C

2: 91 percent / K₂CO₃ / dimethylformamide / 36 h / 20 °C

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0500875

Reference yield:

: 405-31-2
bis(4-fluorophenyl)disulfide

: 226397-38-2
1-tert-butyl 4-ethyl 4-{[4-(phenylthio)phenyl]sulfonyl}piperidine-1,4-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran / 1.5 h / 0 °C

1.2: 75 percent / tetrahydrofuran / 20 h / 20 °C

2.1: 60 percent / MCPBA / CH₂Cl₂ / 20 h / 0 °C

3.1: 91 percent / K₂CO₃ / dimethylformamide / 36 h / 20 °C

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0500875