N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-benzyl-N''-(tert-butoxycarbonyl)aminoguanidine

Base Information

Chemical Name:N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-benzyl-N''-(tert-butoxycarbonyl)aminoguanidine
CAS No.:947748-64-3
Molecular Formula:C₂₇H₃₈N₄O₅S
Molecular Weight:530.689
Hs Code.:

Synonyms:N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-benzyl-N''-(tert-butoxycarbonyl)aminoguanidine

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Chemical Property of N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-benzyl-N''-(tert-butoxycarbonyl)aminoguanidine

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Technology Process of N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-benzyl-N''-(tert-butoxycarbonyl)aminoguanidine

There total 3 articles about N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-benzyl-N''-(tert-butoxycarbonyl)aminoguanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 773147-13-0
N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-benzylthiourea

: 870-46-2
t-butoxycarbonylhydrazine

: 947748-64-3
N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-benzyl-N''-(tert-butoxycarbonyl)aminoguanidine

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1055/s-2007-983706

Reference yield:

: 773147-11-8
(2,2,5,7,8-pentamethylchroman-6-sulfonyl)isothiocyanate

: 947748-64-3
N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-benzyl-N''-(tert-butoxycarbonyl)aminoguanidine

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / CH₂Cl₂ / 0.5 h / 20 °C

2: 98 percent / EDCI*HCl / CH₂Cl₂ / 0.5 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1055/s-2007-983706

Reference yield:

: 112160-39-1
2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride

: 947748-64-3
N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-benzyl-N''-(tert-butoxycarbonyl)aminoguanidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 100 percent / NH₃ / CH₂Cl₂ / 0.33 h / 0 °C

2.1: KOH / benzene / 24 h / Heating

2.2: 75 percent / COCl₂ / toluene / 0 - 20 °C

3.1: 100 percent / CH₂Cl₂ / 0.5 h / 20 °C

4.1: 98 percent / EDCI*HCl / CH₂Cl₂ / 0.5 h / 20 °C

With potassium hydroxide; ammonia; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; benzene;
DOI:10.1055/s-2007-983706