2-(METHYLAMINO)NICOTINONITRILE

Base Information

• Chemical Name: 2-(METHYLAMINO)NICOTINONITRILE
• CAS No.: 52583-87-6
• Molecular Formula: C7H7N3
• Molecular Weight: 133.153
• Hs Code.: 2933399090
• Mol file: 52583-87-6.mol

Synonyms:2-(Methylamino)nicotinonitrile;2-(methylamino)pyridine-3-carbonitrile;3-Pyridinecarbonitrile, 2-(methylamino)-;

Chemical Property of 2-(METHYLAMINO)NICOTINONITRILE

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Melting Point: 85-87 °C
• Refractive Index: 1.553
• Boiling Point: 287.4 °C at 760 mmHg
• Flash Point: 127.6 °C
• PSA: 48.71000
• Density: 1.13 g/cm³
• LogP: 1.06798
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-(Methylamino)-3-cyanopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(METHYLAMINO)NICOTINONITRILE

There total 5 articles about 2-(METHYLAMINO)NICOTINONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-chloro-3-pyridinecarbonitrile (6602-54-6) + methylamine (74-89-5) → 2-(methylamino)-nicotinonitrile (52583-87-6)

Guidance literature:

In water; at 80 ℃; for 2h;

Reference yield: 75.0%

N-Methylformamide (123-39-7) + 2-chloro-3-pyridinecarbonitrile (6602-54-6) → 2-(methylamino)-nicotinonitrile (52583-87-6)

Guidance literature:

for 4h; Reflux; neat (no solvent);

DOI:10.1590/S0103-50532010000800005

Reference yield: 50.0%

N-methyl-acetamide (79-16-3) + 2-chloro-3-pyridinecarbonitrile (6602-54-6) → 2-(methylamino)-nicotinonitrile (52583-87-6)

Guidance literature:

for 28h; Reflux; neat (no solvent);

DOI:10.1590/S0103-50532010000800005

upstream raw materials:

2-chloro-3-pyridinecarbonitrile

methylamine

N-methyl-acetamide

N-Methylformamide

Downstream raw materials:

2-(methylamino)pyridine-3-carboxamide

Refernces

• 1、 -. "Posaconazole derivative, pharmaceutical composition and use thereof". Page/Page column 247. . Retrieved 2020/01/22.
• 2、 -. "HYDROXYL PURINE COMPOUNDS AND USE THEREOF". Paragraph 0267; 0268. . Retrieved 2018/06/09.