2-(2,4-Dichlorophenoxy)ethanethioamide

Base Information

• Chemical Name: 2-(2,4-Dichlorophenoxy)ethanethioamide
• CAS No.: 2302-32-1
• Molecular Formula: C₈H₇Cl₂NOS
• Molecular Weight: 236.122
• Hs Code.: 2930909090
• European Community (EC) Number: 678-853-9
• DSSTox Substance ID: DTXSID70390783
• Wikidata: Q82187808
• Mol file: 2302-32-1.mol

Synonyms:2-(2,4-dichlorophenoxy)ethanethioamide;2302-32-1;Ethanethioamide, 2-(2,4-dichlorophenoxy)-;2-(2,4-Dichlorophenoxy)thioacetamide;2-(2,4-dichlorophenoxy)-thioacetamide;Ethanethioamide,2-(2,4-dichlorophenoxy)-;SCHEMBL7104960;DTXSID70390783;AGDXYFYNDRKKSF-UHFFFAOYSA-N;MFCD00172128;AKOS000167987;CS-0320648;FT-0634188;2E-022;1,3-OXATHIOLANE-2-CARBOXYLICACID,5-OXO-;J-505473

Chemical Property of 2-(2,4-Dichlorophenoxy)ethanethioamide

Chemical Property:

• Vapor Pressure: 1.34E-05mmHg at 25°C
• Melting Point: 139-141 °C
• Refractive Index: 1.634
• Boiling Point: 367.7 °C at 760 mmHg
• Flash Point: 176.2 °C
• PSA: 67.34000
• Density: 1.452 g/cm³
• LogP: 3.35860
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 234.9625404
• Heavy Atom Count: 13
• Complexity: 191

Purity/Quality:

98%Min ^*data from raw suppliers

2-(2,4-Dichlorophenoxy)thioacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)Cl)OCC(=S)N

Technology Process of 2-(2,4-Dichlorophenoxy)ethanethioamide

There total 5 articles about 2-(2,4-Dichlorophenoxy)ethanethioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2,4-dichlorophenoxy)acetaldehyde (17944-27-3) → 2,4-dichlorophenoxythioacetamide (2302-32-1)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride, sodium hydroxide / aq. ethanol; H₂O / Ambient temperature

2: acetic anhydride / Heating

3: hydrogen sulphide gas, triethylamine, pyridine / Ambient temperature

With pyridine; sodium hydroxide; hydrogen sulfide; hydroxylamine hydrochloride; acetic anhydride; triethylamine; In ethanol; water;

Reference yield:

2-(2,4-dichlorophenoxy)acetonitrile (3956-63-6) → 2,4-dichlorophenoxythioacetamide (2302-32-1)

Guidance literature:

With pyridine; hydrogen sulfide; triethylamine; Ambient temperature;

Reference yield:

2,4-dichlorophenoxyacetaldoxime (2776-05-8) → 2,4-dichlorophenoxythioacetamide (2302-32-1)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic anhydride / Heating

2: hydrogen sulphide gas, triethylamine, pyridine / Ambient temperature

With pyridine; hydrogen sulfide; acetic anhydride; triethylamine;

upstream raw materials:

2-(2,4-dichlorophenoxy)acetonitrile

methyl 2,4-dichlorophenoxyacetate

(2,4-dichlorophenoxy)acetaldehyde

2,4-dichlorophenoxyacetaldoxime

Downstream raw materials:

2-(2,4-dichlorophenoxymethyl)-4-(1'-adamantyl)thiazole

2-(2,4-dichlorophenoxymethyl)-4-(5'-nitro-2'-furyl)thiazole

2-(2,4-dichlorophenoxymethyl)-4-(2'-pyrazinyl)thiazole

Refernces