(R)-4-benzyl-3-(3-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-propionyl)-oxazolidin-2-one

Base Information

Chemical Name:(R)-4-benzyl-3-(3-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-propionyl)-oxazolidin-2-one
CAS No.:1207681-53-5
Molecular Formula:C₂₈H₃₀N₂O₄
Molecular Weight:458.557
Hs Code.:

Synonyms:(R)-4-benzyl-3-(3-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-propionyl)-oxazolidin-2-one

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Chemical Property of (R)-4-benzyl-3-(3-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-propionyl)-oxazolidin-2-one

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Technology Process of (R)-4-benzyl-3-(3-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-propionyl)-oxazolidin-2-one

There total 4 articles about (R)-4-benzyl-3-(3-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-propionyl)-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1207681-52-4
3-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-propionic acid

: 40217-17-2,90719-32-7,120574-96-1,102029-44-7
(R)-4-(phenylmethyl)-2-oxazolidinone

: 1207681-53-5
(R)-4-benzyl-3-(3-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-propionyl)-oxazolidin-2-one

Guidance literature:: With pivaloyl chloride; triethylamine; In toluene; at 80 ℃; for 22.5h; Reflux; Inert atmosphere;

Reference yield:

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 1207681-53-5
(R)-4-benzyl-3-(3-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-propionyl)-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: potassium carbonate / toluene / 113 h / 20 °C / Reflux; Inert atmosphere

3.1: water; lithium hydroxide monohydrate / 1,4-dioxane / Inert atmosphere

3.2: pH 6 - 7 / Inert atmosphere

4.1: triethylamine; pivaloyl chloride / toluene / 22.5 h / 80 °C / Reflux; Inert atmosphere

With lithium hydroxide monohydrate; water; pivaloyl chloride; potassium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; toluene;

Reference yield:

: 1207681-51-3
3-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-propionic acid methyl ester

: 1207681-53-5
(R)-4-benzyl-3-(3-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-propionyl)-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide monohydrate / 1,4-dioxane / Inert atmosphere

1.2: pH 6 - 7 / Inert atmosphere

2.1: triethylamine; pivaloyl chloride / toluene / 22.5 h / 80 °C / Reflux; Inert atmosphere

With lithium hydroxide monohydrate; water; pivaloyl chloride; triethylamine; In 1,4-dioxane; toluene;