(R)-4-benzyl-3-((R)-3-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-2-thiocyanato-propionyl)-oxazolidin-2-one

Base Information

Chemical Name:(R)-4-benzyl-3-((R)-3-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-2-thiocyanato-propionyl)-oxazolidin-2-one
CAS No.:1207681-54-6
Molecular Formula:C₂₉H₂₉N₃O₄S
Molecular Weight:515.633
Hs Code.:

Synonyms:(R)-4-benzyl-3-((R)-3-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-2-thiocyanato-propionyl)-oxazolidin-2-one

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Chemical Property of (R)-4-benzyl-3-((R)-3-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-2-thiocyanato-propionyl)-oxazolidin-2-one

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Technology Process of (R)-4-benzyl-3-((R)-3-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-2-thiocyanato-propionyl)-oxazolidin-2-one

There total 5 articles about (R)-4-benzyl-3-((R)-3-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-2-thiocyanato-propionyl)-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1207681-53-5
(R)-4-benzyl-3-(3-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-propionyl)-oxazolidin-2-one

: 163276-49-1
1-thiocyanatopyrrolidine-2,5-dione

: 1207681-54-6
(R)-4-benzyl-3-((R)-3-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-2-thiocyanato-propionyl)-oxazolidin-2-one

Guidance literature:: (R)-4-benzyl-3-(3-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-propionyl)-oxazolidin-2-one; With lithium diisopropyl amide; In tetrahydrofuran; hexanes; at -78 ℃; for 0.5h; Inert atmosphere;

1-thiocyanatopyrrolidine-2,5-dione; In tetrahydrofuran; hexanes; at -78 ℃; for 1.83333h; Inert atmosphere;

Reference yield:

: 144809-26-7
2-(5-ethyl-pyridin-2-yl)ethyl methanesulfonate

: 1207681-54-6
(R)-4-benzyl-3-((R)-3-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-2-thiocyanato-propionyl)-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / toluene / 113 h / 20 °C / Reflux; Inert atmosphere

2.1: water; lithium hydroxide monohydrate / 1,4-dioxane / Inert atmosphere

2.2: pH 6 - 7 / Inert atmosphere

3.1: triethylamine; pivaloyl chloride / toluene / 22.5 h / 80 °C / Reflux; Inert atmosphere

4.1: lithium diisopropyl amide / tetrahydrofuran; hexanes / 0.5 h / -78 °C / Inert atmosphere

4.2: 1.83 h / -78 °C / Inert atmosphere

With lithium hydroxide monohydrate; water; pivaloyl chloride; potassium carbonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; hexanes; toluene;

Reference yield:

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 1207681-54-6
(R)-4-benzyl-3-((R)-3-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-2-thiocyanato-propionyl)-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: potassium carbonate / toluene / 113 h / 20 °C / Reflux; Inert atmosphere

3.1: water; lithium hydroxide monohydrate / 1,4-dioxane / Inert atmosphere

3.2: pH 6 - 7 / Inert atmosphere

4.1: triethylamine; pivaloyl chloride / toluene / 22.5 h / 80 °C / Reflux; Inert atmosphere

5.1: lithium diisopropyl amide / tetrahydrofuran; hexanes / 0.5 h / -78 °C / Inert atmosphere

5.2: 1.83 h / -78 °C / Inert atmosphere

With lithium hydroxide monohydrate; water; pivaloyl chloride; potassium carbonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; hexanes; dichloromethane; toluene;