N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-2-(3-methoxybenzyl)-2-methyl-3-(ptolyl)propanamide

Base Information

Chemical Name:N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-2-(3-methoxybenzyl)-2-methyl-3-(ptolyl)propanamide
CAS No.:1623774-96-8
Molecular Formula:C₃₁H₃₆N₄O₂
Molecular Weight:496.652
Hs Code.:

Synonyms:N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-2-(3-methoxybenzyl)-2-methyl-3-(ptolyl)propanamide

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Chemical Property of N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-2-(3-methoxybenzyl)-2-methyl-3-(ptolyl)propanamide

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Technology Process of N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-2-(3-methoxybenzyl)-2-methyl-3-(ptolyl)propanamide

There total 6 articles about N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-2-(3-methoxybenzyl)-2-methyl-3-(ptolyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1623774-86-6
N-(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)-2,2-dimethyl-3-(p-tolyl)propanamide

: 36282-40-3
(3-methoxyphenyl)magnesium bromide

: 1623774-96-8
N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-2-(3-methoxybenzyl)-2-methyl-3-(ptolyl)propanamide

Guidance literature:: N-(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)-2,2-dimethyl-3-(p-tolyl)propanamide; (3-methoxyphenyl)magnesium bromide; With N,N,N,N,-tetramethylethylenediamine; zinc dibromide; In tetrahydrofuran; at 20 ℃; for 0.166667h; Inert atmosphere; Schlenk technique;

With iron(III)-acetylacetonate; o-phenylenebis(diphenylphosphine); In toluene; at 20 ℃; for 0.166667h;

With 1,2-dichloro-2-methylpropane; In tetrahydrofuran; toluene; at 80 ℃; for 16h;
DOI:10.1002/anie.201311024

Reference yield:

: 1310826-33-5
2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-amine

: 1623774-96-8
N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-2-(3-methoxybenzyl)-2-methyl-3-(ptolyl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / Inert atmosphere; Schlenk technique

2.1: N,N,N,N,-tetramethylethylenediamine; zinc dibromide / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere; Schlenk technique

2.2: 0.17 h / 20 °C

2.3: 16 h / 80 °C

With N,N,N,N,-tetramethylethylenediamine; triethylamine; zinc dibromide; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.201311024

Reference yield:

: 622-79-7
benzyl azide

: 1623774-96-8
N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-2-(3-methoxybenzyl)-2-methyl-3-(ptolyl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 24 h / 20 °C / Inert atmosphere; Schlenk technique

2.1: triethylamine / dichloromethane / Inert atmosphere; Schlenk technique

3.1: N,N,N,N,-tetramethylethylenediamine; zinc dibromide / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere; Schlenk technique

3.2: 0.17 h / 20 °C

3.3: 16 h / 80 °C

With copper(ll) sulfate pentahydrate; N,N,N,N,-tetramethylethylenediamine; sodium L-ascorbate; triethylamine; zinc dibromide; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1002/anie.201311024