5-(Methylthio)Thiophene-2-Carbaldehyde

Base Information

• Chemical Name: 5-(Methylthio)Thiophene-2-Carbaldehyde
• CAS No.: 24445-35-0
• Molecular Formula: C6H6 O S2
• Molecular Weight: 266.05
• Hs Code.: 29349990
• European Community (EC) Number: 806-953-6
• DSSTox Substance ID: DTXSID30371755
• Wikidata: Q72491677
• Mol file: 24445-35-0.mol

Synonyms:5-(Methylthio)Thiophene-2-Carbaldehyde;24445-35-0;5-(Methylthio)thiophene-2-carboxaldehyde;5-methylsulfanylthiophene-2-carbaldehyde;5-(methylsulfanyl)thiophene-2-carbaldehyde;MFCD00173744;2-Thiophenecarboxaldehyde,5-(methylthio)-;2-formyl-5-methylthiothiphene;SCHEMBL1838483;DTXSID30371755;2-Formyl-5-(methylthio)thiophene;RKXYTFTZODXDEF-UHFFFAOYSA-N;5-methylmercapto-2-thiophenaldehyde;ZAA44535;5-Methylthio-2-thiophenecarbaldehyde;2-Formyl-5-(methylsulphanyl)thiophene;AKOS009157395;DS-6448;5-methylmercaptothiophene-2-carbaldehyde;2-methylmercaptothiophen-5-carboxaldehyde;5-methylmercaptothiophene-2-carboxaldehyde;5-Methylsulfanyl-thiophene-2-carbaldehyde;BP-10383;FT-0619722;M2448;5-(Methylsulphanyl)thiophene-2-carboxaldehyde;EN300-181575;T72147;A817310;5-(methylthio)thiophene-2-carbaldehyde, AldrichCPR;Z367487368;5-(Methylthio)thiophene-2-carbaldehyde

Chemical Property of 5-(Methylthio)Thiophene-2-Carbaldehyde

Chemical Property:

• Vapor Pressure: 0.00424mmHg at 25°C
• Melting Point: 104 °C
• Refractive Index: 1.6624 (589.3 nm 20℃)
• Boiling Point: 86°C 0,3mm
• Flash Point: 122.3°C
• PSA: 70.61000
• Density: 1.28g/cm³
• LogP: 2.28250
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 157.98600716
• Heavy Atom Count: 9
• Complexity: 105

Purity/Quality:

97% ^*data from raw suppliers

5-(Methylthio)thiophene-2-carboxaldehyde >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-43-41-37/38-22
• Safety Statements: 26-36/37/39-39-36/37-60-37-23

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CSC1=CC=C(S1)C=O

Technology Process of 5-(Methylthio)Thiophene-2-Carbaldehyde

There total 6 articles about 5-(Methylthio)Thiophene-2-Carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(methylsulfanyl)thiophene (5780-36-9) + N-Methylformamide (123-39-7) → 5-(methylthio)thiophene-2-carboxaldehyde (24445-35-0)

Guidance literature:

With phosphorus trichloride;

Reference yield:

thiophene-2-carbaldehyde (98-03-3) → 5-(methylthio)thiophene-2-carboxaldehyde (24445-35-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / benzene / 12 h / Heating

In benzene;

DOI:10.1016/S0040-4020(01)91401-2

Reference yield:

2-(methylsulfanyl)thiophene (5780-36-9) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 5-(methylthio)thiophene-2-carboxaldehyde (24445-35-0)

Guidance literature:

With trichlorophosphate;

DOI:10.1039/jr9540000237

upstream raw materials:

2-(methylsulfanyl)thiophene

N,N-dimethyl-formamide

N-methyl-N-phenylformamide

Dimethyldisulphide

Downstream raw materials:

5-methylsulfanyl-thiophene-2-carbaldehyde-(4-nitro-phenylhydrazone)

5-(methylthio)thiophene-2-carboxylic acid

5-methanesulfonyl-thiophene-2-carbaldehyde

5-Methylsulfinyl-2-thiophencarbaldehyd-thiosemicarbazon