N-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)-N-methylpiperidine-4-amine

Base Information

Chemical Name:N-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)-N-methylpiperidine-4-amine
CAS No.:1447121-17-6
Molecular Formula:C₂₀H₂₉FN₄O₄S
Molecular Weight:440.539
Hs Code.:

Synonyms:N-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)-N-methylpiperidine-4-amine

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Chemical Property of N-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)-N-methylpiperidine-4-amine

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Technology Process of N-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)-N-methylpiperidine-4-amine

There total 5 articles about N-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)-N-methylpiperidine-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 859538-50-4
3-fluoro-4-(methanesulfonyl)phenol

: 1447123-04-7
2-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)(methyl)amino)ethylmethane sulfonate

: 1447121-17-6
N-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)-N-methylpiperidine-4-amine

Guidance literature:: With potassium carbonate; In acetone; for 3h; Inert atmosphere; Reflux;

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 1447121-17-6
N-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)-N-methylpiperidine-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran; N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

2.1: iron; acetic acid / water / Inert atmosphere

3.1: sulfuric acid; sodium nitrite / tetrahydrofuran; water / 3 h / 0 °C / Inert atmosphere

3.2: kappa (II) nitrate; kappa (I) oxide / 0.5 h / 20 °C

4.1: Oxone / tetrahydrofuran; water / 3 h / 0 - 20 °C / Inert atmosphere

5.1: potassium carbonate / acetone / 3 h / Inert atmosphere; Reflux

With Oxone; sulfuric acid; iron; potassium carbonate; acetic acid; sodium nitrite; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 20901-69-3
3-fluoro-4-(methylthio)benzeneamine

: 1447121-17-6
N-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)-N-methylpiperidine-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid; sodium nitrite / tetrahydrofuran; water / 3 h / 0 °C / Inert atmosphere

1.2: kappa (II) nitrate; kappa (I) oxide / 0.5 h / 20 °C

2.1: Oxone / tetrahydrofuran; water / 3 h / 0 - 20 °C / Inert atmosphere

3.1: potassium carbonate / acetone / 3 h / Inert atmosphere; Reflux

With Oxone; sulfuric acid; potassium carbonate; sodium nitrite; In tetrahydrofuran; water; acetone;