N-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)-N-methylpiperidine-4-amine trifluoroacetate

Base Information

• Chemical Name: N-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)-N-methylpiperidine-4-amine trifluoroacetate
• CAS No.: 1447121-20-1
• Molecular Formula: C₂HF₃O₂*C₂₀H₂₉FN₄O₄S
• Molecular Weight: 554.563
• Mol file: 1447121-20-1.mol

Synonyms:

Chemical Property of N-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)-N-methylpiperidine-4-amine trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)-N-methylpiperidine-4-amine trifluoroacetate

There total 5 articles about N-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)-N-methylpiperidine-4-amine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)-N-methylpiperidine-4-amine (1447121-17-6) + trifluoroacetic acid (76-05-1) → N-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)-N-methylpiperidine-4-amine trifluoroacetate (1447121-20-1)

Guidance literature:

In ethyl acetate; for 0.5h; Inert atmosphere; Reflux;

Reference yield:

3,4-difluoronitrobenzene (369-34-6) → N-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)-N-methylpiperidine-4-amine trifluoroacetate (1447121-20-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: tetrahydrofuran; N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

2.1: iron; acetic acid / water / Inert atmosphere

3.1: sulfuric acid; sodium nitrite / tetrahydrofuran; water / 3 h / 0 °C / Inert atmosphere

3.2: kappa (II) nitrate; kappa (I) oxide / 0.5 h / 20 °C

4.1: Oxone / tetrahydrofuran; water / 3 h / 0 - 20 °C / Inert atmosphere

5.1: potassium carbonate / acetone / 3 h / Inert atmosphere; Reflux

6.1: ethyl acetate / 0.5 h / Inert atmosphere; Reflux

With Oxone; sulfuric acid; iron; potassium carbonate; acetic acid; sodium nitrite; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; acetone;

Reference yield:

3-fluoro-4-(methylthio)benzeneamine (20901-69-3) → N-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)-N-methylpiperidine-4-amine trifluoroacetate (1447121-20-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sulfuric acid; sodium nitrite / tetrahydrofuran; water / 3 h / 0 °C / Inert atmosphere

1.2: kappa (II) nitrate; kappa (I) oxide / 0.5 h / 20 °C

2.1: Oxone / tetrahydrofuran; water / 3 h / 0 - 20 °C / Inert atmosphere

3.1: potassium carbonate / acetone / 3 h / Inert atmosphere; Reflux

4.1: ethyl acetate / 0.5 h / Inert atmosphere; Reflux

With Oxone; sulfuric acid; potassium carbonate; sodium nitrite; In tetrahydrofuran; water; ethyl acetate; acetone;

upstream raw materials:

N-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)-N-methylpiperidine-4-amine

trifluoroacetic acid

(2-fluoro-4-nitrophenyl)(methyl)sulfone

3,4-difluoronitrobenzene

Refernces