3-Methoxy-phthalic acid 2-(6-ethyl-5,6,7,8-tetrahydro-naphthalen-1-yl) ester 1-methyl ester

Base Information

• Chemical Name: 3-Methoxy-phthalic acid 2-(6-ethyl-5,6,7,8-tetrahydro-naphthalen-1-yl) ester 1-methyl ester
• CAS No.: 78772-93-7
• Molecular Formula: C₂₂H₂₄O₅
• Molecular Weight: 368.43
• Mol file: 78772-93-7.mol

Synonyms:3-Methoxy-phthalic acid 2-(6-ethyl-5,6,7,8-tetrahydro-naphthalen-1-yl) ester 1-methyl ester

Chemical Property of 3-Methoxy-phthalic acid 2-(6-ethyl-5,6,7,8-tetrahydro-naphthalen-1-yl) ester 1-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Methoxy-phthalic acid 2-(6-ethyl-5,6,7,8-tetrahydro-naphthalen-1-yl) ester 1-methyl ester

There total 3 articles about 3-Methoxy-phthalic acid 2-(6-ethyl-5,6,7,8-tetrahydro-naphthalen-1-yl) ester 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-methoxy-6-methoxycarbonylbenzoic acid (60314-07-0) + 6-ethyl-5,6,7,8-tetrahydro-1-naphthol (78772-92-6) → 3-Methoxy-phthalic acid 2-(6-ethyl-5,6,7,8-tetrahydro-naphthalen-1-yl) ester 1-methyl ester (78772-93-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 5h; Heating;

DOI:10.1021/ja00404a048

Reference yield:

5-Methoxy-1-tetralone (33892-75-0) → 3-Methoxy-phthalic acid 2-(6-ethyl-5,6,7,8-tetrahydro-naphthalen-1-yl) ester 1-methyl ester (78772-93-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) potassium tert-butoxide, 2.) hydrogen, HCl / 2.) Pd/C / 1.) tert-butyl alcohol, 2.) HOAc

2: 48percent HBr / 120 °C

3: 90 percent / trifluoroacetic acid / CH₂Cl₂ / 5 h / Heating

With hydrogenchloride; potassium tert-butylate; hydrogen bromide; hydrogen; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane;

DOI:10.1021/ja00404a048

Reference yield:

2-Ethyl-5-methoxy-1,2,3,4-tetrahydro-naphthalene (916883-80-2) → 3-Methoxy-phthalic acid 2-(6-ethyl-5,6,7,8-tetrahydro-naphthalen-1-yl) ester 1-methyl ester (78772-93-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 48percent HBr / 120 °C

2: 90 percent / trifluoroacetic acid / CH₂Cl₂ / 5 h / Heating

With hydrogen bromide; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/ja00404a048

upstream raw materials:

2-methoxy-6-methoxycarbonylbenzoic acid

6-ethyl-5,6,7,8-tetrahydro-1-naphthol

5-Methoxy-1-tetralone

2-Ethyl-5-methoxy-1,2,3,4-tetrahydro-naphthalene

Downstream raw materials:

2-(6-Ethyl-1-hydroxy-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-3-methoxy-benzoic acid methyl ester

2-(6-Ethyl-1-hydroxy-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-3-methoxy-benzoic acid