3,5-Dichloro-4-methoxybenzonitrile

Base Information

Chemical Name:3,5-Dichloro-4-methoxybenzonitrile
CAS No.:3336-38-7
Molecular Formula:C8H5Cl2NO
Molecular Weight:202.04
Hs Code.:
DSSTox Substance ID:DTXSID60440721
Wikidata:Q82257097
ChEMBL ID:CHEMBL4994600

Synonyms:3,5-Dichloro-4-methoxybenzonitrile;3336-38-7;3,5-dichloro-4-methoxy-benzonitrile;CHEMBL4994600;DTXSID60440721;AKOS000113909;BS-25216;BB 0244155;CS-0212889

Suppliers and Price of 3,5-Dichloro-4-methoxybenzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 3,5-Dichloro-4-methoxybenzonitrile

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:200.9748192
Heavy Atom Count:12
Complexity:189

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1Cl)C#N)Cl

Technology Process of 3,5-Dichloro-4-methoxybenzonitrile

There total 6 articles about 3,5-Dichloro-4-methoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32407-11-7
3,5-dichloro-4-methoxyaniline

: 3336-38-7
3,5-dichloro-4-methyloxybenzonitrile

Guidance literature:: DOI:10.1002/hlca.19470300127

Reference yield:

: 24295-27-0
methyl 3,5-dichloro-4-methoxybenzoate

: 3336-38-7
3,5-dichloro-4-methyloxybenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Heating

2: oxalyl dichloride; dimethyl sulfoxide; triethylamine / 1.) CH₂Cl₂, -70 deg C, 1.5 h, 2.) CH₂Cl₂, -70 deg C - RT, 3 h

3: pyridine; hydroxylamine hydrochloride / 1.) RT, 15 min, 2.) toluene, reflux, 4 h

With pyridine; lithium aluminium tetrahydride; oxalyl dichloride; hydroxylamine hydrochloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran;
DOI:10.1021/jm9700225

Reference yield:

: 41727-58-6
3,5-dichloro-4-methoxybenzaldehyde

: 3336-38-7
3,5-dichloro-4-methyloxybenzonitrile

Guidance literature:: With pyridine; hydroxylamine hydrochloride; Yield given. Multistep reaction; 1.) RT, 15 min, 2.) toluene, reflux, 4 h;
DOI:10.1021/jm9700225